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p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
Stable Identifier
R-MMU-5218870
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
MLKL binds PIPs (Mus musculus)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
RIPK3 is phosphorylated (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
RIPK3 phosphorylates MLKL (Mus musculus)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
ATP binds MLKL (Mus musculus)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
ITCH polyubiquitinates MLKL at K50 (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xK63PolyUb-K50,p-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
MLKL binds FLOT1, FLOT2 (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
MLKL binds IP4, IP5 and IP6 (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
MLKL binds ITCH (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Mus musculus)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
MLKL binds PDCD6IP and SDCBP (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
PELI1 binds activated RIPK1:RIPK3 (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Stimuli-sensing channels (Mus musculus)
TRP channels (Mus musculus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
TRPs transport extracellular Ca2+ to cytosol (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
phospho-p-S166-RIPK1 [cytosol]
(Mus musculus)
phospho-p-S199,227-RIPK3 [cytosol]
(Mus musculus)
Participates
as an input of
PELI1 binds activated RIPK1:RIPK3 (Mus musculus)
RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)
as an output of
RIPK3 is phosphorylated (Mus musculus)
as a repeated unit of
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Mus musculus)
Inferred From
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
(Homo sapiens)
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