Reactome | Slc38a9 [lysosomal membrane]

Slc38a9 [lysosomal membrane]

Stable Identifier

R-MMU-5215938

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

lysosomal membrane

Synonyms

SLC38A9, Q8BGD6

Locations in the PathwayBrowser

Expand all

Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - Active MTORC1 binds the ULK1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Active MTORC1 phosphorylates ULK1 (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - MTORC1 dissociates from ULK complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MAF1 translocates to the nucleus (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
        
        mTORC1 phosphorylates MAF1 (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
- MTOR signalling (Mus musculus)
  - AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Mus musculus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Formation of active mTORC1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - SLC38A9 binds Ragulator:Rag dimers (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Slc38a9 [lysosomal membrane] (Mus musculus)
    - Slc38a9 [lysosomal membrane] (Mus musculus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Slc38a9 [lysosomal membrane] (Mus musculus)
    - Slc38a9 [lysosomal membrane] (Mus musculus)
  - mTORC1 phosphorylates AKT1S1 (Mus musculus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
  - mTORC1-mediated signalling (Mus musculus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Slc38a9 [lysosomal membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BGD6

Gene Names

Slc38a9

Reference Genes

BioGPS Gene:268706 Slc38a9

ENSEMBL:ENSMUSG00000047789

KEGG:mmu:268706 Slc38a9

Monarch:268706 Slc38a9

NCBI Gene:268706 Slc38a9

UCSC:Q8BGD6 Slc38a9

Reference Transcript

Other Identifiers

10407192

10407209

106805_at

116930_at

1436456_at

1454283_at

1455360_at

1455612_at

1456338_at

165758_at

17289908

268706

4329504

4335059

4341112

4355182

4371003

4429803

4510613

4537274

4546027

4557234

4589517

4590664

4651240

4692735

4721625

4723695

4743046

4745368

4762156

4802202

4858414

4877430

4885042

4918064

4938122

4968193

4970266

5014756

5043105

5044696

5067638

5106646

5110805

5180507

5182419

5185292

5234908

5291576

5295684

5313806

5350879

5438448

5456436

5473799

5478023

5491568

5527392

5550125

5595759

5610333

5613039

A_52_P236963

A_52_P356228

A_52_P578768

A_55_P2382110

A_55_P2935006

GE1498784

GE1573119

GO:0003333

GO:0005085

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0006865

GO:0006867

GO:0006868

GO:0008289

GO:0015171

GO:0015179

GO:0015182

GO:0015186

GO:0015190

GO:0015485

GO:0015803

GO:0016020

GO:0031902

GO:0032008

GO:0032935

GO:0034618

GO:0046872

GO:0055085

GO:0061459

GO:0071230

GO:0071986

GO:0098772

GO:0140299

GO:1903826

GO:1904263

GO:1990877

ILMN_1230743

ILMN_1242435

ILMN_2442122

ILMN_2494904

ILMN_2502093

ILMN_2748372

ILMN_2748373

ILMN_2831268

mMC021463

mMC022176

mMC025466

mMR027524

mMR028715

Participates

as a component of

as an input of

SLC38A9 binds Ragulator:Rag dimers (Mus musculus)

Inferred From

SLC38A9 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

NP_848861.1, XP_006517733.1, XP_030103136.1

ENSEMBL

ENSMUSP00000052172, ENSMUST00000052514, ENSMUSG00000047789

PRO

Q8BGD6

GlyGen

Q8BGD6

MGI

1918839

Cite Us!