Sirt1 deacetylates Taf1b in SL1 complex

Stable Identifier
R-MMU-5211233
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Sirt1 deacetylates Taf1b in SL1 complex
Sirt1, an NAD-dependent deacetylase, deacetylates the Taf1b subunit of the SL1 complex, which regulates transcription by RNA polymerase I (Muth et al. 2001). Deacetylation of Taf1b inhibits the transcription of rRNA genes.
Literature References
PubMed ID Title Journal Year
11250901 Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

Muth, V, Nadaud, S, Grummt, I, Voit, R

EMBO J 2001
Participants
Input
Output
Catalyst Activity

NAD-dependent protein lysine deacetylase activity of Sirt1 [nucleoplasm]

Physical Entity
Sirt1 [nucleoplasm] (Mus musculus)
Activity
NAD-dependent protein lysine deacetylase activity (GO:0034979)
Orthologous Events
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
Authored
May, B  (2013-11-15)
Reviewed
Voit, R  (2014-01-21)
Grummt, I  (2014-01-21)
Created
May, B  (2013-12-09)
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