Reactome | Ncbp1 [nucleoplasm]

Ncbp1 [nucleoplasm]

Stable Identifier

R-MMU-51469

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

NCBP1, Q3UYV9

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA Polymerase II Pre-transcription Events (Mus musculus)
    - Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Elongation (Mus musculus)
    - Formation of RNA Pol II elongation complex (Mus musculus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
    - Formation of the Early Elongation Complex (Mus musculus)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - Formation of DSIF:NELF:early elongation complex (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Termination (Mus musculus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
    - Cleavage of mRNA at the 3'-end (Mus musculus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
    - Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)
      - Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20 [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
    - Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)
      - Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        Ncbp1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3UYV9

Gene Names

Ncbp1

Reference Genes

BioGPS Gene:433702 Ncbp1

ENSEMBL:ENSMUSG00000028330

KEGG:mmu:433702 Ncbp1

Monarch:433702 Ncbp1

NCBI Gene:433702 Ncbp1

UCSC:Q3UYV9 Ncbp1

Reference Transcript

RefSeq:NM_001033201.3 Ncbp1

Other Identifiers

102400_at

10504703

112397_at

1433663_s_at

17413789

4317261

433702

4337663

4385503

4390823

4409870

4421255

4597521

4649529

4655069

4756405

4811342

4845610

4854373

4965955

5029840

5050955

5053994

5087620

5129622

5158322

5191551

5193167

5222244

5235510

5287241

5300690

5336990

5411231

5465707

A_51_P328669

A_52_P510852

A_55_P2713395

A_66_P108085

GE115331

GO:0000184

GO:0000245

GO:0000339

GO:0000340

GO:0000380

GO:0000398

GO:0002191

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005846

GO:0006351

GO:0006355

GO:0006370

GO:0006401

GO:0006406

GO:0006408

GO:0006417

GO:0006446

GO:0006913

GO:0008334

GO:0008380

GO:0016070

GO:0016071

GO:0030307

GO:0031047

GO:0031053

GO:0031124

GO:0031442

GO:0032968

GO:0034518

GO:0035194

GO:0035195

GO:0042789

GO:0043226

GO:0048026

GO:0050684

GO:0051028

GO:0051607

GO:0065003

GO:0098542

GO:1990904

ILMN_3162184

Participates

as a component of

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)

as an input of

Formation of cap binding complex (CBC) (Mus musculus)

Other forms of this molecule

Ncbp1 [cytosol]

Inferred From

NCBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001028373.2

ENSEMBL

ENSMUSG00000028330, ENSMUST00000030014, ENSMUSP00000030014

PRO

Q3UYV9

GlyGen

Q3UYV9

MGI

1891840

PDB

3UL0, 3UKZ

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