Reactome | NCBP2 [nucleoplasm]

NCBP2 [nucleoplasm]

Stable Identifier

R-MMU-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q9CQ49

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA Polymerase II Pre-transcription Events (Mus musculus)
    - Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Elongation (Mus musculus)
    - Formation of RNA Pol II elongation complex (Mus musculus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
    - Formation of the Early Elongation Complex (Mus musculus)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - Formation of DSIF:NELF:early elongation complex (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Termination (Mus musculus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
    - Cleavage of mRNA at the 3'-end (Mus musculus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
    - Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)
      - Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20 [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
    - Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)
      - Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex [nucleoplasm] (Mus musculus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Mus musculus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Mus musculus)
        
        NCBP2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQ49

Reference Genes

BioGPS Gene:68092

ENSEMBL:ENSMUSG00000022774

KEGG:mmu:68092

Monarch:68092

NCBI Gene:68092

UCSC:Q9CQ49

Reference Transcript

RefSeq:NM_026554.4

Other Identifiers

10434998

1423045_at

1423046_s_at

1450847_at

17324722

4464641

4500076

4613057

4747794

4824939

4992350

5033352

5211803

5251811

5284303

68092

94509_at

A_51_P151433

A_52_P83321

A_55_P2068772

A_55_P2893159

GE41299

GO:0000184

GO:0000339

GO:0000340

GO:0000380

GO:0000398

GO:0002191

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005737

GO:0005846

GO:0006351

GO:0006355

GO:0006397

GO:0006406

GO:0006408

GO:0006417

GO:0006446

GO:0006913

GO:0008334

GO:0008380

GO:0016071

GO:0017069

GO:0031047

GO:0031053

GO:0031124

GO:0031442

GO:0032968

GO:0034518

GO:0035195

GO:0042789

GO:0043226

GO:0045292

GO:0046833

GO:0051028

ILMN_2686808

ILMN_2788260

ILMN_2788263

mMC021629

w83938_s_at

Participates

as a component of

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)

as an input of

Formation of cap binding complex (CBC) (Mus musculus)

Other forms of this molecule

NCBP2 [cytosol]

Inferred From

NCBP2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_080830.1

ENSEMBL

ENSMUSG00000022774, ENSMUST00000023460, ENSMUSP00000023460

PRO

Q9CQ49

MGI

1915342

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