Bmal1:Clock,Npas2 heterodimer is phosphorylated and translocates to the nucleus

Stable Identifier
R-MMU-508656
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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PNG
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Bmal1:Clock,Npas2 heterodimer is phosphorylated and translocates to the nucleus

Bmal1 (Arntl), Clock, and Npas2 are phosphorylated by unknown kinases. The phosphorylation is dependent on the heterodimerization of Bmal1 with Clock or Npas2. Phosphorylated Bmal1:Clock/Npas2 is a much stronger transactivator of gene expression than is unphosphorylated Bmal1:Clock/Npas2.

Literature References
PubMed ID Title Journal Year
12897057 BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system

Antoch, MP, Kondratova, AA, Gorbacheva, VY, Kondratov, RV, Gudkov, AV, Chernov, MV

Genes Dev 2003
19414601 Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription

Fukada, Y, Yoshitane, H, Takao, T, Du, NH, Satomi, Y, Okano, T

Mol Cell Biol 2009
11875063 The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

Eide, EJ, Vielhaber, EL, Virshup, DM, Hinz, WA

J Biol Chem 2002
19330005 CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

Hirayama, J, Nagai, K, Isojima, Y, Tamaru, T, Takamatsu, K, Sassone-Corsi, P, Norioka, S

Nat Struct Mol Biol 2009
16980631 BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer

Jung, NC, Son, GH, Lee, BJ, Chang, SH, Kim, K, Kwon, I, Lee, KH, Lee, J

Mol Cell Biol 2006
16628007 Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES

Antoch, MP, Kondratova, AA, Gorbacheva, VY, Lee, C, Kondratov, RV, Chernov, MV

Cell Cycle 2006
17115977 Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression

Fortier, EE, Cermakian, N, Martineau, V, Dardente, H

Biochem J 2007
Participants
Input
Output
Orthologous Events
BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)
Authored
May, B  (2010-02-20)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Albrecht, U  (2010-06-23)
Created
May, B  (2010-02-16)
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