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Birc3 [cytosol]
Stable Identifier
R-MMU-50845
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
BIRC3, O08863
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
TNFR2 non-canonical NF-kB pathway (Mus musculus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Mus musculus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF3 binds BAFFR:BAFF (Mus musculus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAFs bind RANK:RANKL (Mus musculus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Mus musculus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF2:cIAP1,2 [cytosol] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
RIP2 is K63 polyubiquitinated (Mus musculus)
RIP2 ubiquitin ligases [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)
RIP1 ubiqutin ligases [cytosol] (Mus musculus)
c-IAP2:UBE2D [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)
HIF1A,BIRC2,BIRC3 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
USP19:HIF1A,BIRC2,BIRC3 [cytosol] (Mus musculus)
HIF1A,BIRC2,BIRC3 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
RIPK3 binds RIPK1 (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signalling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CLIP3 and CYLD bind TNF signaling complex (Mus musculus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
RIPK1 is deubiquitinated (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Mus musculus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNFR1-induced NFkappaB signaling pathway (Mus musculus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
BIRC2,3,4 [cytosol] (Mus musculus)
Birc3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O08863
Gene Names
Birc3
Reference Genes
BioGPS Gene:11796 Birc3
ENSEMBL:ENSMUSG00000032000
KEGG Gene (Mus musculus):11796 Birc3
Monarch:11796 Birc3
NCBI Gene:11796 Birc3
Reference Transcript
RefSeq:NM_007464.3 Birc3
Participant Of
hasMember
BIRC2,3,4 [cytosol]
HIF1A,BIRC2,BIRC3 [cytosol]
hasComponent
c-IAP2:UBE2D [cytosol]
hasCandidate
RIP2 ubiquitin ligases [cytosol]
Other forms of this molecule
Birc3 [cytosol]
Birc3 [cytosol]
Inferred From
BIRC3 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_031490.2
PRO
O08863
MGI
1197007
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