Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36)

Stable Identifier
R-MMU-508217
Type
Reaction [transition]
Species
Mus musculus
Compartment
secretory granule lumen
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36)
Prohormone convertase 1 (PC1/3, NEC, Pcsk1) cleaves proglucagon adjacent to amino acids 98 and 127 to yield Glucagon-like peptide-1 (7-36).
Literature References
PubMed ID Title Journal Year
12145326 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

Lindberg, I, Dey, A, Ugleholdt, R, Steiner, DF, Carroll, R, Zhang, C, Holst, JJ, Norrbom, C, Zhu, X, Zhou, A, Laurent, V

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Pcsk1 [secretory granule lumen]

Physical Entity
Pcsk1 [secretory granule lumen] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
Authored
May, B  (2010-02-11)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2010-02-11)
Cite Us!