Reactome | Mta3 [nucleoplasm]

Mta3 [nucleoplasm]

Stable Identifier

R-MMU-4657013

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

MTA3, Q924K8

Locations in the PathwayBrowser

Expand all

Chromatin organization (Mus musculus)

- Chromatin modifying enzymes (Mus musculus)
  - HDACs deacetylate histones (Mus musculus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)
    - HDAC1:2-containing complex deacetylate histones (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase I Transcription (Mus musculus)
  - RNA Polymerase I Promoter Clearance (Mus musculus)
    - RNA Polymerase I Transcription Initiation (Mus musculus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        SALL4 recruits NuRD to PTEN gene (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)
        
        Mta3 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q924K8 Mta3

Gene Names

Mta3

Chain

chain:1-591

Reference Genes

BioGPS Gene:116871 Mta3

ENSEMBL:ENSMUSG00000055817.19 Mta3

KEGG Gene (Mus musculus):116871 Mta3

Monarch:116871 Mta3

NCBI Gene:116871 Mta3

UCSC:Q924K8 Mta3

Reference Transcript

Other Identifiers

10447167

106039_at

116871

1421402_at

1451352_s_at

17340017

4357760

4406865

4464100

4466717

4507735

4648377

4839082

4928135

4956205

4962605

4969681

5048742

5100790

5148245

5208583

5322892

5351747

5463025

5569467

5588517

5596621

5597534

A_52_P119393

A_55_P1971347

A_55_P2022094

GE42125

GO:0000086

GO:0000122

GO:0000278

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008283

GO:0010971

GO:0016581

GO:0030154

GO:0042659

GO:0042826

GO:0043226

GO:0043231

GO:0043565

GO:0044877

GO:0045892

GO:0045893

GO:0046872

GO:0120325

GO:0140110

GO:1904197

GO:1990739

GO:2000736

ILMN_1259783

mMC023248

Participates

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Mta3 [nucleoplasm]

Inferred From

MTA3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_473423.1, NP_001164525.1

Ensembl

ENSMUSP00000068931, ENSMUSG00000055817, ENSMUST00000067826

PRO

Q924K8

MGI

2151172

PDB

2CRG