Crebbp acetylates replicative histone H2B, H3, H4

Stable Identifier
Reaction [transition]
Mus musculus
SVG |   | PPTX  | SBGN
Crebbp acetylates replicative histone H2B, H3, H4

CREBBP (CBP) is named after its interaction with the CRE-binding protein CREB, though it interacts with many other proteins. It is thought to act as an integrator of signals from various pathways (Goodman & Smolik 2000), which compete for a limited amount of nuclear CREBBP. CREBBP and EP300 (p300) are closely related and have overlapping functions but also unique properties, particularly in vivo (Kalkhoven 2004). Both proteins form a physical bridge between DNA-binding transcription factors and the RNA polymerase II complex. Histones are believed to be the main acetylation targets of CREBBP and EP300, but their ability to acetylate and thereby regulate transcription factors such as p53 (Gu & Roeder 1997) is considered significant additional function (Kasper et al. 2006).

CREBBP has intrinsic histone acetyltransferase (HAT) activity on lysine-12 of H2B, lysine-14 of H3 and lysine-8 of H4 (Bannister & Kouzarides 1996, Rekowski & Giannis 2010, Barrett et al. 2011).

Homozygous knockout of Crebbp results in embryonic lethality (Tanaka et al. 1997). Focal deletion of Crebbp demonstrates that it is critical for the in vivo acetylation of lysines on histones H2B, H3 and H4, and cannot be compensated for by the p300 (Barrett et al. 2011).

Genomic aberrations in CREBBP are associated with Rubinstein-Taybi syndrome (Torress et al. 2013).

Literature References
PubMed ID Title Journal Year
21508930 Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory

Barrett, RM, Malvaez, M, Kramar, E, Matheos, DP, Arrizon, A, Cabrera, SM, Lynch, G, Greene, RW, Wood, MA

Neuropsychopharmacology 2011
Catalyst Activity

histone acetyltransferase activity of Crebbp [nucleoplasm]

Orthologous Events
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