Reactome | Il3 [extracellular region]

Il3 [extracellular region]

Stable Identifier

R-MMU-450059

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IL3, P01586

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - Activation of STAT5a/b by JAK2 (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - IL3RB is phosphorylated on Ser-585 (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - JAK2 is phosphorylated, activated (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - SHP1 and SHP2 bind the common beta chain (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, p(Y593)-Bc [plasma membrane] (Mus musculus)
        
        IL3RA:IL3:p(Y593)-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - STAT5 is recruited by JAK2 (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - The receptor is activated (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - Tyrosine kinases phosphorylate the receptor (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Mus musculus)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
      - p-STAT5 dissociates from the receptor complex (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Mus musculus)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Mus musculus)
        
        IL3:IL3RA [plasma membrane] (Mus musculus)
        
        Il3 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P01586

Gene Names

Il3

Reference Genes

BioGPS Gene:16187 Il3

ENSEMBL:ENSMUSG00000018914

ENSEMBL:ENSMUSG00000018914.6 Il3

KEGG Gene (Mus musculus):16187 Il3

Monarch:16187 Il3

NCBI Gene:16187 Il3

UCSC:P01586 Il3

Reference Transcript

RefSeq:NM_010556.4 Il3

Other Identifiers

10385918

1450566_at

16187

17262823

4417737

4436215

5124533

5133197

5278336

5473121

5598844

94086_at

A_52_P98630

GE35600

GO:0001558

GO:0001666

GO:0001783

GO:0001934

GO:0002244

GO:0002376

GO:0002573

GO:0002763

GO:0002903

GO:0005125

GO:0005135

GO:0005576

GO:0005615

GO:0005975

GO:0006091

GO:0006110

GO:0006914

GO:0006955

GO:0007155

GO:0007165

GO:0007254

GO:0008083

GO:0008283

GO:0008284

GO:0009725

GO:0010468

GO:0010507

GO:0012501

GO:0019221

GO:0023052

GO:0030097

GO:0030154

GO:0030224

GO:0030890

GO:0033024

GO:0033026

GO:0033028

GO:0033033

GO:0035162

GO:0035304

GO:0036211

GO:0038156

GO:0042098

GO:0042100

GO:0042102

GO:0042531

GO:0046330

GO:0048018

GO:0048856

GO:0050731

GO:0055086

GO:0070662

GO:0070668

GO:0097192

GO:0098772

GO:1901135

GO:1901534

ILMN_1247309

mMC011263

x02732_s_at

Participates

as a component of

IL3:IL3RA [plasma membrane] (Mus musculus)

Inferred From

IL3 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_034686.2

Ensembl

ENSMUSG00000018914, ENSMUST00000019058, ENSMUSP00000019058

PRO

P01586

MGI

96552

PDB

2L3O

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