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Il12a [extracellular region]
Stable Identifier
R-MMU-447212
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
IL12A, P43431
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-12 family signaling (Mus musculus)
Interleukin-12 signaling (Mus musculus)
IL12 bound to IL12R internalises (Mus musculus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12B translocates from late endosome lumen to extracellular region (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
Interleukin-12 binds Interleukin-12 receptor (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
Interleukin-12 dissociates from Interleukin-12 receptor (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
Interleukin-35 Signalling (Mus musculus)
IL35 binds IL-12RB2:IL6ST receptor (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35 binds IL12RB2:IL12RB2 receptor (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35 binds IL27RA:IL12RB2 receptor (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35 binds IL6ST:IL6ST receptor (Mus musculus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
Interleukin-35 translocates from the ER lumen to the extracellular region (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Mus musculus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Mus musculus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Mus musculus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Mus musculus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Mus musculus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Mus musculus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Mus musculus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
STAT1 associates with IL6ST:IL6ST (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Mus musculus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
STAT4 binds IL12RB2:IL12RB2 (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Mus musculus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Mus musculus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Mus musculus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Mus musculus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Mus musculus)
IL35 [extracellular region] (Mus musculus)
Il12a [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P43431 Il12a
Gene Names
Il12a
Chain
signal peptide:1-22, chain:23-215
Reference Genes
BioGPS Gene:16159 Il12a
ENSEMBL:ENSMUSG00000027776.13 Il12a
KEGG Gene (Mus musculus):16159 Il12a
Monarch:16159 Il12a
NCBI Gene:16159 Il12a
UCSC:P43431 Il12a
Reference Transcript
RefSeq:NM_001159424.2 Il12a
RefSeq:NM_008351.3 Il12a
Other Identifiers
100773_at
10492540
1425454_a_at
16159
17398218
4366063
4593525
4718517
4773025
4786221
4939957
5058850
5077635
5131017
5257897
5396003
5566773
A_52_P442228
A_55_P1960436
GE34631
GO:0001916
GO:0002376
GO:0002860
GO:0005125
GO:0005143
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0006955
GO:0007155
GO:0007165
GO:0008083
GO:0008283
GO:0009986
GO:0010224
GO:0012501
GO:0016477
GO:0023052
GO:0030154
GO:0031410
GO:0031904
GO:0032496
GO:0032700
GO:0032729
GO:0032816
GO:0032946
GO:0034393
GO:0035711
GO:0035722
GO:0036211
GO:0042098
GO:0042102
GO:0042163
GO:0042531
GO:0042832
GO:0043226
GO:0043514
GO:0045513
GO:0045582
GO:0045785
GO:0045954
GO:0046982
GO:0048018
GO:0048662
GO:0048856
GO:0048870
GO:0050671
GO:0050709
GO:0051135
GO:0071222
GO:0097191
GO:0098542
GO:0098586
GO:0098772
GO:1900747
GO:1903588
GO:2000510
ILMN_2706462
ILMN_2773980
M86672_s_at
mMC011607
mMR026687
Participates
as a component of
IL35 [extracellular region] (Mus musculus)
IL12A:IL12B [extracellular region] (Mus musculus)
Other forms of this molecule
Il12a [extracellular region]
Il12a [endosome lumen]
Il12a [Golgi lumen]
Il12a [endoplasmic reticulum lumen]
Il12a [endoplasmic reticulum lumen]
Il12a [late endosome lumen]
Inferred From
IL12A [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001152896.1
,
NP_032377.1
Ensembl
ENSMUSG00000027776
,
ENSMUSP00000103446
,
ENSMUST00000107816
PRO
P43431
MGI
96539
PDB
8OE0
,
8CR6
,
8PB1
,
8ODZ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35228
2
Ebi3 [endoplasmic reticulum lumen]
(R-MMU-8950622)
Ebi3 [extracellular region]
(R-MMU-448418)
0.589
2
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