Reactome | Gpr68 [plasma membrane]

Gpr68 [plasma membrane]

Stable Identifier

R-MMU-444625

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

GPR68, Q8BFQ3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gq complex dissociates (Mus musculus)
        
        GPCRs that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)
        
        pH sensing receptors:H+ [plasma membrane] (Mus musculus)
        
        pH sensing receptors [plasma membrane] (Mus musculus)
        
        Gpr68 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BFQ3

Gene Names

Gpr68

Reference Genes

BioGPS Gene:238377 Gpr68

ENSEMBL:ENSMUSG00000047415

ENSEMBL:ENSMUSG00000047415.13 Gpr68

KEGG Gene (Mus musculus):238377 Gpr68

Monarch:238377 Gpr68

NCBI Gene:238377 Gpr68

UCSC:Q8BFQ3 Gpr68

Reference Transcript

Other Identifiers

10402136

10402140

116488_f_at

116489_r_at

1455000_at

17283293

238377

4525675

4553767

4642712

4685040

4997583

5054228

5082139

5118025

5156296

5158344

5261646

5352440

5362095

5371765

5384886

5474450

5504188

5521433

A_51_P296815

A_55_P1956083

GE1521225

GO:0002376

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0030073

GO:0030154

GO:0030224

GO:0032024

GO:0035774

GO:0036035

GO:0045656

GO:0048856

GO:0060089

GO:0071467

GO:2001206

ILMN_2732996

mMC019109

Participates

as a member of

pH sensing receptors [plasma membrane] (Mus musculus)

Inferred From

GPR68 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001171144.1, NP_780702.1, NP_001171145.1

Ensembl

ENSMUSP00000105692, ENSMUSP00000057510, ENSMUSP00000105693, ENSMUSG00000047415, ENSMUST00000110065, ENSMUST00000053668, ENSMUST00000110066

PRO

Q8BFQ3

MGI

2441763

HMDB Protein

HMDBP13666