Interaction of L1 with Laminin-1

Stable Identifier
R-MMU-443785
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of L1 with Laminin-1
While HNK-1 (human natural killer 1) carbohydrate is expressed on several kinds of cell adhesion molecules in the nervous system, L1CAM is the major carrier of HNK-1 carbohydrate. HNK-1 also functions as a ligand for Laminin. L1 binds in a concentration-dependent and saturating manner to Laminin in presence of HNK-1.
Literature References
PubMed ID Title Journal Year
9003039 L1/HNK-1 carbohydrate- and beta 1 integrin-dependent neural cell adhesion to laminin-1

Hall, H, Carbonetto, S, Schachner, M

J Neurochem 1997
18024472 Expression and function of the HNK-1 carbohydrate

Kizuka, Y, Oka, S, Morita, I, Kakuda, S

J Biochem 2008
Participants
Input
Output
Entity On Other Cell
Orthologous Events
Interaction of L1 with Laminin-1 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
Cite Us!