Reactome | SAP-90 [plasma membrane]

SAP-90 [plasma membrane]

Stable Identifier

R-MMU-443606

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Disks large homolog 4, Dlg4, DLG4_MOUSE

Locations in the PathwayBrowser for interactor UniProt:Q8IUH5 ZDH17

Expand all

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases activate CIT (Mus musculus)
        
        CIT-3 binds DLG4 (Mus musculus)
        
        SAP-90 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q62108 Dlg4

Gene Names

Dlg4, Dlgh4, Psd95

Chain

chain:1-724

Reference Genes

BioGPS Gene:13385 Dlg4

ENSEMBL:ENSMUSG00000020886.18 Dlg4

KEGG Gene (Mus musculus):13385 Dlg4

Monarch:13385 Dlg4

NCBI Gene:13385 Dlg4

UCSC:Q62108 Dlg4

Reference Transcript

Other Identifiers

10377725

104175_at

13385

1419580_at

1419581_at

1459105_at

1460261_at

17251900

4313490

4363939

4401078

4403097

4438840

4439215

4477146

4564844

4577383

4625468

4726489

4766197

4781438

4791927

4904538

4961279

5005976

5104426

5112403

5155415

5198100

5207651

5311356

5446170

5485274

5515996

A_52_P153721

A_55_P2008053

D50621_s_at

GE42485

GO:0002091

GO:0005102

GO:0005109

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005856

GO:0005886

GO:0005911

GO:0007155

GO:0007163

GO:0007204

GO:0007268

GO:0007626

GO:0008021

GO:0008076

GO:0008092

GO:0014069

GO:0016020

GO:0016188

GO:0016192

GO:0016323

GO:0019894

GO:0019900

GO:0019901

GO:0019903

GO:0023052

GO:0030054

GO:0030154

GO:0030165

GO:0030424

GO:0030425

GO:0030863

GO:0031410

GO:0031594

GO:0031697

GO:0031698

GO:0031748

GO:0031812

GO:0032281

GO:0032839

GO:0033130

GO:0034330

GO:0035176

GO:0035254

GO:0035255

GO:0035418

GO:0035641

GO:0035865

GO:0042043

GO:0042220

GO:0042995

GO:0043005

GO:0043197

GO:0043226

GO:0044224

GO:0044300

GO:0044306

GO:0044307

GO:0044309

GO:0044877

GO:0045184

GO:0045197

GO:0045202

GO:0045211

GO:0048168

GO:0048169

GO:0048856

GO:0050775

GO:0050806

GO:0050877

GO:0050885

GO:0051965

GO:0055085

GO:0060076

GO:0060997

GO:0061024

GO:0065003

GO:0071625

GO:0071944

GO:0097060

GO:0097061

GO:0097109

GO:0097110

GO:0097113

GO:0097120

GO:0098609

GO:0098793

GO:0098794

GO:0098839

GO:0098919

GO:0098970

GO:0098978

GO:0099562

GO:0099645

GO:0150012

GO:1904719

GO:1990635

GO:2000310

GO:2000463

GO:2000821

ILMN_2497403

mMC018318

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

Dlg4 [endocytic vesicle membrane]

Dlg4 [cytosol]

Inferred From

DLG4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_031890.1, NP_001103222.1

Ensembl

ENSMUST00000231415, ENSMUST00000108588, ENSMUST00000108589, ENSMUSG00000020886, ENSMUSP00000104229, ENSMUSP00000104230, ENSMUSP00000156345

PRO

Q62108

MGI

1277959

Interactors (116)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01097 Grin2b	7	p-Nr2b [plasma membrane] (R-MMU-3928470) phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-MMU-3928477) Grin2b [plasma membrane] (R-MMU-3928478) Grin2b [transport vesicle membrane] (R-MMU-9610571) Grin2b [endoplasmic reticulum membrane] (R-MMU-9610361) GRIN2B [endoplasmic reticulum membrane] (R-MMU-9609765) GRIN2B [plasma membrane] (R-MMU-419558)	0.951	19
UniProt:P35436 Grin2a	2	GRIN2A [endoplasmic reticulum membrane] (R-MMU-9609760) Grin2a [plasma membrane] (R-MMU-9006562)	0.928	15
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.888	13
UniProt:Q8R4I7 NETO1			0.753	7
UniProt:Q9WV31 ARC			0.748	7
UniProt:Q91ZX7	2	LRP1 [endocytic vesicle membrane] (R-MMU-2230981) LRP1 [plasma membrane] (R-MMU-1454844)	0.716	4
UniProt:Q9R111	1	GDA [cytosol] (R-MMU-56087)	0.708	6
UniProt:Q61423	1	Kcna4 [plasma membrane] (R-MMU-977474)	0.659	3
UniProt:Q80TG9	1	Lrfn2 [plasma membrane] (R-MMU-197665)	0.656	3
UniProt:Q14B62 PTHD1			0.649	8
UniProt:Q4ACU6	1	Shank3 [cytosol] (R-MMU-6794277)	0.643	4
UniProt:P16388	1	Kcna1 [plasma membrane] (R-MMU-977482)	0.643	4
UniProt:Q9JIA1	1	Lgi1 [extracellular region] (R-MMU-5678671)	0.643	5
UniProt:P62482	3	KCNAB2 [specific granule membrane] (R-MMU-6799627) KCNAB2 [plasma membrane] (R-MMU-1297366) KCNAB2 [tertiary granule membrane] (R-MMU-6800890)	0.643	4
UniProt:P23819	3	phospho-p-S880-GRIA2 [plasma membrane] (R-MMU-3004500) GRIA2 [endocytic vesicle membrane] (R-MMU-3004487) GRIA2 [plasma membrane] (R-MMU-3004502)	0.643	4
UniProt:P16330 CN37			0.643	4
UniProt:P63141	1	Kcna2 [plasma membrane] (R-MMU-977477)	0.643	4
UniProt:Q9R1V6	1	Adam22 [plasma membrane] (R-MMU-5678678)	0.643	5
UniProt:P11798 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-MMU-432796) p-T286-Camk2a [nucleoplasm] (R-MMU-9608160) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-MMU-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-MMU-4332334) CAMK2A [cytosol] (R-MMU-4332329) phospho-p-T286-CAMK2A [cytosol] (R-MMU-445368)	0.623	4
UniProt:Q8K4G5 ABLM1			0.623	5
UniProt:Q91XM9	2	Dlg2 [cytosol] (R-MMU-6794230) Dlg2 [plasma membrane] (R-MMU-9610662)	0.623	6
UniProt:P46460	1	NSF [cytosol] (R-MMU-264471)	0.623	5
UniProt:P63085 Mapk1	9	phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-MMU-112354) phospho-p-T185,Y187-MAPK1 [cytosol] (R-MMU-109853) MAPK1 [cytosol] (R-MMU-59282) MAPK1 [nucleoplasm] (R-MMU-199960) p-T183,Y185-Mapk1 [nucleoplasm] (R-MMU-198682) phospho-p-T185-MAPK1 [cytosol] (R-MMU-9635773) MAPK1 [azurophil granule lumen] (R-MMU-6799225) MAPK1 [extracellular region] (R-MMU-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-MMU-6800964)	0.623	4
UniProt:P70175 Dlg3	3	Dlg3 [cytosol] (R-MMU-6794232) Dlg3 [plasma membrane] (R-MMU-443586) Dlg3 [plasma membrane] (R-MMU-443609)	0.623	4
UniProt:Q8BKX1	1	Baiap2 [cytosol] (R-MMU-442574)	0.623	4
UniProt:Q811D0 Dlg1	3	SAP-97 [plasma membrane] (R-MMU-443608) Dlg1 [cytosol] (R-MMU-416332) Dlg1 [plasma membrane] (R-MMU-375977)	0.623	4
UniProt:Q62179 SEM4B			0.61	5
UniProt:P63001 Rac1	7	RAC1 [ficolin-1-rich granule membrane] (R-MMU-6804802) RAC1 [secretory granule membrane] (R-MMU-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-MMU-2316446) RAC1 [endoplasmic reticulum membrane] (R-MMU-5672076) Rac1 [plasma membrane] (R-MMU-2316449) RAC1 [cytosol] (R-MMU-442615) Rac1 [plasma membrane] (R-MMU-421093)	0.564	3
UniProt:P30873	1	Sstr1 [plasma membrane] (R-MMU-374741)	0.544	3
UniProt:P49660	1	Sstr4 [plasma membrane] (R-MMU-374745)	0.544	3
UniProt:Q61090 Fzd7	2	Fzd7 [plasma membrane] (R-MMU-517515) Fzd7 [plasma membrane] (R-MMU-517394)	0.543	4
UniProt:P12960 Cntn1	1	Cntn1 [plasma membrane] (R-MMU-373623)	0.527	2
UniProt:Q5DU25 IQEC2			0.527	3
UniProt:Q91V61 SFXN3			0.527	3
UniProt:Q6GQW0 ABTB3			0.527	3
UniProt:Q61626	1	Grik5 [plasma membrane] (R-MMU-450197)	0.527	2
UniProt:P50396	1	Gdi1 [cytosol] (R-MMU-195106)	0.527	2
UniProt:D3YZU1	1	Shank1 [cytosol] (R-MMU-6794274)	0.527	2
UniProt:Q61171 Prdx2	2	p-T89-Prdx2 [cytosol] (R-MMU-8868593) Prdx2 [cytosol] (R-MMU-8868588)	0.527	2
UniProt:Q62261 Sptbn1	2	Sptbn1 [cytosol] (R-MMU-9662390) Sptbn1 [cytosol] (R-MMU-420048)	0.527	2
UniProt:P61205	2	ARF3 [cytosol] (R-MMU-6807733) ARF3 [Golgi membrane] (R-MMU-1604608)	0.527	2
UniProt:Q68FD5	6	Cltc [cytosol] (R-MMU-350824) Cltc [trans-Golgi network membrane] (R-MMU-2130474) Cltc [endolysosome membrane] (R-MMU-8870827) Cltc [clathrin-coated endocytic vesicle membrane] (R-MMU-5138450) Cltc [lysosomal membrane] (R-MMU-2980660) Cltc [plasma membrane] (R-MMU-2980668)	0.527	4
UniProt:O35449 PRRT1			0.527	2
UniProt:P62259 Ywhae	1	14-3-3 epsilon [cytosol] (R-MMU-1445119)	0.527	2
UniProt:Q922F4 Tubb6	5	Polyglycyl-TUBB6 [cytosol] (R-MMU-8867396) Polyglutamyl-TUBB6 [cytosol] (R-MMU-8867399) TUBB6 [axonemal microtubule] (R-MMU-5610438) Tubulin beta-6 chain [cytosol] (R-MMU-2316323) TUBB6 [cytosol] (R-MMU-191698)	0.527	3
UniProt:P52189	1	Kcnj4 [plasma membrane] (R-MMU-975336)	0.527	3
UniProt:Q99JY8	1	Plpp3 [plasma membrane] (R-MMU-76132)	0.527	2
UniProt:Q9Z307	1	Kcnj16 [plasma membrane] (R-MMU-975281)	0.527	3
UniProt:Q6PHZ2 Camk2d	5	phospho-p-T287-CAMK2D [plasma membrane] (R-MMU-432794) p-T287-Camk2d [nucleoplasm] (R-MMU-9608162) phospho-p-T287-CAMK2D [endocytic vesicle membrane] (R-MMU-417002) CAMK2D [cytosol] (R-MMU-9611357) phospho-p-T287-CAMK2D [cytosol] (R-MMU-445370)	0.527	2
UniProt:Q9Z2W9	2	GRIA3 [endocytic vesicle membrane] (R-MMU-3004509) GRIA3 [plasma membrane] (R-MMU-3004508)	0.527	3
UniProt:Q9Z2W8	2	GRIA4 [endocytic vesicle membrane] (R-MMU-416303) GRIA4 [plasma membrane] (R-MMU-392229)	0.527	2
UniProt:P59999	1	Arpc4 [cytosol] (R-MMU-200813)	0.527	2
UniProt:Q8C1B7 SEP11			0.527	2
UniProt:P35700 Prdx1	3	p-T90-Prdx1 [cytosol] (R-MMU-8868582) Prdx1 [cytosol] (R-MMU-5629198) Prdx1 [cytosol] (R-MMU-8868585)	0.527	2
UniProt:Q9D415	1	Dlgap1 [plasma membrane] (R-MMU-6794239)	0.527	4
UniProt:Q9R0P5 DEST			0.527	3
UniProt:Q9D2M8	2	Ube2v2 [cytosol] (R-MMU-947624) Ube2v2 [nucleoplasm] (R-MMU-5682543)	0.527	2
UniProt:P16390	1	Kcna3 [plasma membrane] (R-MMU-977475)	0.527	3
UniProt:Q5SQX6	1	Cyfip2 [cytosol] (R-MMU-1671642)	0.527	3
UniProt:P63328 Ppp3ca	2	PPP3CA [nucleoplasm] (R-MMU-2685599) Ppp3ca [cytosol] (R-MMU-2025986)	0.527	3
UniProt:P62874 Gnb1	3	Gnb1 [photoreceptor disc membrane] (R-MMU-55373) G-protein beta 1 subunit [plasma membrane] (R-MMU-428095) G-protein beta 1 subunit [cytosol] (R-MMU-4551475)	0.527	3
UniProt:Q5SSL4	1	Abr [cytosol] (R-MMU-2975963)	0.527	2
UniProt:Q9CZY3	1	Ube2v1 [cytosol] (R-MMU-205753)	0.527	3
UniProt:Q69ZK9	1	Nlgn2 [plasma membrane] (R-MMU-6788639)	0.527	2
UniProt:P39087	2	Edited GRIK2 (GluR6) [plasma membrane] (R-MMU-451318) GRIK2 [plasma membrane] (R-MMU-450192)	0.527	2
UniProt:Q3UXZ6 FA81A			0.527	3
UniProt:P60202 MYPR			0.527	3
UniProt:P31324 KAP3			0.527	2
UniProt:Q8BJ42	1	Dlgap2 [plasma membrane] (R-MMU-6794266)	0.527	3
UniProt:Q06890	4	Clu [extracellular region] (R-MMU-349732) Clu [platelet alpha granule lumen] (R-MMU-349733) Clu [extracellular region] (R-MMU-6810626) Clu [extracellular region] (R-MMU-6810660)	0.527	2
UniProt:P18872 Gnao1	1	Gnao1 [plasma membrane] (R-MMU-4551533)	0.527	3
UniProt:O88602	2	Cacng2 [endocytic vesicle membrane] (R-MMU-416846) Cacng2 [plasma membrane] (R-MMU-210375)	0.527	2
UniProt:Q9JM63	1	KCNJ10 [plasma membrane] (R-MMU-975290)	0.527	3
UniProt:P15105	1	GLUL [cytosol] (R-MMU-70603)	0.527	3
UniProt:O35129	1	Phb2 [mitochondrial inner membrane] (R-MMU-8953721)	0.527	3
UniProt:P08551	1	Nefl [cytosol] (R-MMU-432284)	0.527	3
UniProt:Q68EF6 BEGIN			0.527	2
UniProt:P63143	1	KCNAB1 [plasma membrane] (R-MMU-3325592)	0.527	2
UniProt:Q9QYS2	1	GRM3 [plasma membrane] (R-MMU-420509)	0.527	2
UniProt:Q8R0S2 IQEC1			0.527	3
UniProt:P46660 AINX			0.527	2
UniProt:Q03391	2	GRIN2D [endoplasmic reticulum membrane] (R-MMU-9609766) GRIN2D [plasma membrane] (R-MMU-419561)	0.527	3
UniProt:P47754 Capza2	2	Capza2 [cytosol] (R-MMU-9663289) Capza2 [extracellular region] (R-MMU-879417)	0.527	3
UniProt:B2RSH2 Gnai1	1	Gnai1 [plasma membrane] (R-MMU-8964313)	0.527	2
UniProt:P59672 ANS1A			0.527	2
UniProt:Q6PFD5	1	Dlgap3 [plasma membrane] (R-MMU-6794269)	0.527	3
UniProt:Q3UHD9 AGAP2			0.527	3
UniProt:P43006	1	SLC1A2 [plasma membrane] (R-MMU-210459)	0.527	3
UniProt:P61982 Ywhag	1	14-3-3 gamma [cytosol] (R-MMU-1445103)	0.527	2
UniProt:Q91XV3	1	Basp1 [plasma membrane] (R-MMU-9715127)	0.527	2
UniProt:Q61553 FSCN1			0.527	3
UniProt:Q8BIZ1 ANS1B			0.527	2
UniProt:F6SEU4	1	Syngap1 [cytosol] (R-MMU-5658217)	0.527	3
UniProt:Q9Z2Q6 SEPT5			0.527	2
UniProt:P42208	1	SEPT2 [cytosol] (R-MMU-5626657)	0.527	2
UniProt:A2CG49	2	phospho-p-KALRN [cytosol] (R-MMU-5692652) KALRN [cytosol] (R-MMU-3006505)	0.527	2
UniProt:P10126	6	Me3K79-EEF1A1 [cytosol] (R-MMU-8932212) Me3K318-EEF1A1 [cytosol] (R-MMU-8932419) EEF1A1 [secretory granule lumen] (R-MMU-6801479) EEF1A1 [extracellular region] (R-MMU-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-MMU-6801528) EEF1A1 [cytosol] (R-MMU-156905)	0.527	2
UniProt:P23818	5	GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-MMU-5689811) GRIA1 [ER to Golgi transport vesicle membrane] (R-MMU-5689810) GRIA1 [endoplasmic reticulum membrane] (R-MMU-5689460) GRIA1 [endocytic vesicle membrane] (R-MMU-3004479) GRIA1 [plasma membrane] (R-MMU-3004495)	0.527	2
UniProt:Q8BX10	2	Pgam5 [mitochondrial outer membrane] (R-MMU-5357787) Pgam5 [mitochondrial outer membrane] (R-MMU-5357797)	0.527	2
UniProt:P49025 Cit	1	Cit [cytosol] (R-MMU-5625896)	0.527	2
UniProt:P48453 Ppp3cb	3	Ppp3cb [cytosol] (R-MMU-2025962) PPP3CB [nucleoplasm] (R-MMU-2685624) PPP3CB [cytosol] (R-MMU-2025869)	0.527	3
UniProt:Q02053	2	UBA1 [nucleoplasm] (R-MMU-8852116) UBA1 [cytosol] (R-MMU-947698)	0.527	2
UniProt:P18760 Cfl1	3	Cofilin-1 [extracellular region] (R-MMU-350721) pCofilin-1 (Ser-3) [cytosol] (R-MMU-421086) Cofilin-1 [cytosol] (R-MMU-350722)	0.527	2
UniProt:P46096	6	SYT1 [clathrin-coated endocytic vesicle membrane] (R-MMU-8869113) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-MMU-210536) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-MMU-372514) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-MMU-917741) SYT1 [plasma membrane] (R-MMU-168786) SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-MMU-372508)	0.527	3
UniProt:A2ARV4	2	LRP2 [clathrin-coated endocytic vesicle membrane] (R-MMU-8869099) LRP2 [plasma membrane] (R-MMU-350083)	0.508	2
UniProt:Q810U4 Nrcam	1	Nrcam [plasma membrane] (R-MMU-443611)	0.508	2
UniProt:P15209 Ntrk2	4	phospho-p-5Y-NTRK2 [plasma membrane] (R-MMU-9026475) Ntrk2 [plasma membrane] (R-MMU-9025038) p-5Y-Ntrk2 [plasma membrane] (R-MMU-9030410) p-5Y,S478-Ntrk2 [plasma membrane] (R-MMU-9033310)	0.499	4
UniProt:Q8R550	3	Sh3kbp1 [cytosol] (R-MMU-182926) Sh3kbp1 [cytosol] (R-MMU-182957) Sh3kbp1 [plasma membrane] (R-MMU-182955)	0.499	3
UniProt:P12023	11	APP(672-713) [extracellular region] (R-MMU-879340) APP(672-711) [extracellular region] (R-MMU-976740) APP [endoplasmic reticulum lumen] (R-MMU-8956696) phospho-p-APP [endoplasmic reticulum lumen] (R-MMU-8957012) APP(18-770) [endosome lumen] (R-MMU-5229077) APP(18-770) [platelet alpha granule lumen] (R-MMU-139835) APP(18-770) [extracellular region] (R-MMU-49335) APP [mitochondrial inner membrane] (R-MMU-9839060) APP (535-695) [cytosol] (R-MMU-9839084) APP-C99 [cytosol] (R-MMU-9617603) APP(18-770) [trans-Golgi network membrane] (R-MMU-5229136)	0.499	4
UniProt:Q8IUH5 ZDH17			0.489	2
UniProt:Q61625 GRID2			0.482	2
UniProt:Q9WUH7 SEM4G			0.463	2
UniProt:Q80TE2 Q80TE2			0.463	4
UniProt:Q64151 SEM4C			0.463	2
UniProt:P35347	1	Crhr1 [plasma membrane] (R-MMU-420166)	0.463	7
UniProt:P23804 Mdm2	12	phospho-Mdm2 [nucleoplasm] (R-MMU-6793669) phospho-Mdm2 [cytosol] (R-MMU-198638) Mdm2 [cytosol] (R-MMU-198644) Mdm2 [nucleoplasm] (R-MMU-69486) phospho-Mdm2 [nucleoplasm] (R-MMU-6792862) phospho-Mdm2 [nucleoplasm] (R-MMU-6795669) phospho-Mdm2 [nucleoplasm] (R-MMU-6804954) Mdm2 [endocytic vesicle membrane] (R-MMU-416849) Mdm2 [plasma membrane] (R-MMU-416843) Mdm2 [cytosol] (R-MMU-9769903) Mdm2 [nucleoplasm] (R-MMU-3000408) Mdm2 [nucleoplasm] (R-MMU-6782472)	0.463	3

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