Pparg:Rxra heterodimer binds to PPARG corepressors

Stable Identifier
R-MMU-442515
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pparg:Rxra heterodimer binds to PPARG corepressors
In mouse 3T3-L1 cells, the PPARG:RXRA heterodimer binds specific the PPRE element, two 6-bp DR-1 motifs separated by 1 nucleotide, in the promoters of target genes such as aP2/Fabp4 even in the absence of fatty acid ligands that activate PPARG (IJpenberg et al. 1997, Okuno et al. 2001). When activating ligands of PPARG are absent PPARG:RXRA recruits corepressors such as Smrt, NCoR, and Hdac33 to maintain the target gene in an inactive state (Tontonoz et al. 1994, Yu et al. 2005, Yoo et al. 2006).
Literature References
PubMed ID Title Journal Year
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
7838715 Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha

Tontonoz, P, Graves, RA, Budavari, AI, Erdjument-Bromage, H, Lui, M, Hu, E, Tempst, P, Spiegelman, BM

Nucleic Acids Res 1994
16407282 Down-regulation of histone deacetylases stimulates adipocyte differentiation

Yoo, EJ, Chung, JJ, Choe, SS, Kim, KH, Kim, JB

J Biol Chem 2006
11139380 Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha

Okuno, M, Arimoto, E, Ikenobu, Y, Nishihara, T, Imagawa, M

Biochem J 2001
9242684 Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element

IJpenberg, A, Jeannin, E, Wahli, W, Desvergne, B

J Biol Chem 1997
15691842 The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis

Yu, C, Markan, K, Temple, KA, Deplewski, D, Brady, MJ, Cohen, RN

J Biol Chem 2005
Participants
Input
Output
Orthologous Events
PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)
Authored
May, B  (2009-05-15)
Reviewed
Sethi, JK  (2011-02-10)
Created
May, B  (2009-09-27)
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