mNOTCH1 coactivator complex bind promoters of Hey genes

Stable Identifier
R-MMU-4396387
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
General
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PNG
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 | PPTX  | SBGN
mNOTCH1 coactivator complex bind promoters of Hey genes

Promoters of Hey1, Hey and Heyl genes contain conserved RBPJ (CSL) binding sites. Cotransfection experiments in mouse fibroblast cell line NIH3T3, human embryonic kidney cell line HEK293 and African green monkey kidney cell line COS-7 showed that a recombinant mouse NICD1 activates transcription of a reporter luciferase gene fused to promoters of either mouse Hey1, Hey2 or Heyl. NICD1-mediated transcriptional activation is lost when RBPJ sites in Hey1 promoter are deleted by PCR-directed mutagenesis (Maier and Gessler 2000).

Literature References
PubMed ID Title Journal Year
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Maier, MM, Gessler, M

Biochem Biophys Res Commun 2000
Participants
Input
Output
Orthologous Events
NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2013-08-23)
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