FADK1 interaction with DCC

Stable Identifier
R-MMU-421693
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FADK1 interaction with DCC
The carboxy (C) terminal domain of FADK1 interacts with the C-terminal P3 domain of DCC. This FADK1-DCC interaction is required for Netrin-1 to stimulate tyrosine phosphorylation and activation of FADK1.
Literature References
PubMed ID Title Journal Year
15494734 Activation of FAK and Src are receptor-proximal events required for netrin signaling

Vikis, HG, Aurandt, J, Shen, TL, Fearon, ER, Lee, J, Lee, SH, Hong, K, Li, W, Guan, JL, Guan, KL, Rao, Y, Han, M, Liu, G

Nat Neurosci 2004
15494733 Focal adhesion kinase in netrin-1 signaling

Chen, ZF, Wang, Q, Xie, Y, Ming, GL, Feng, Z, Sun, DM, Mei, L, Zhao, ZQ, Hong, Y, Song, HJ, Ren, XR, Xiong, WC, Shim, S

Nat Neurosci 2004
Participants
Input
Output
Orthologous Events
FADK1 interaction with DCC (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-05-19)
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