Neogenin binds Netrin-1

Stable Identifier
R-MMU-421688
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Neogenin binds Netrin-1
Netrin-1 is not only involved as an axon guidance cue during the development of nervous system but is also involved in the morphogenesis of the mammary glands. Netrin-1 acts as a short-range attractant and has an adhesive, rather than a guidance, function during mammary gland morphogenesis. In the developing mammary gland, netrin-1 acts locally through neogenin to maintain close apposition of cap cells and prelumenal cells at the leading edge of the TEB (Terminal end bud).
Literature References
PubMed ID Title Journal Year
12636918 Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis

Strickland, P, Srinivasan, K, Hinck, L, Shin, GC, Valdes, A

Dev Cell 2003
Participants
Input
Output
Orthologous Events
Neogenin binds Netrin-1 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-05-19)
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