Activation of Rac1 by FARP2

Stable Identifier
R-MMU-421147
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Rac1 by FARP2
Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.
FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.
Literature References
PubMed ID Title Journal Year
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Zhang, H, Yoshida, J, Toyofuku, T, Kumanogoh, A, Sugimoto, T, Kikutani, H, Hori, M

Nat Neurosci 2005
17607942 The CRMP family of proteins and their role in Sema3A signaling

Strittmatter, SM, Schmidt, EF

Adv Exp Med Biol 2007
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of FARP2 [cytosol]

Physical Entity
FARP2 [cytosol] (Mus musculus)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rac1 by FARP2 (Homo sapiens)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-05-15)
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