Reactome | Rac1:GDP [plasma membrane]

Drug ADME (Mus musculus)

- Azathioprine ADME (Mus musculus)
  - p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Mus musculus)
    - Rac1:GDP [plasma membrane] (Mus musculus)

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PTK6 (Mus musculus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
      - Activation of RAC1 by the PXN:CRK complex (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by MET (Mus musculus)
    - MET promotes cell motility (Mus musculus)
      - MET activates RAP1 and RAC1 (Mus musculus)
        
        DOCK7 activates RAC1 (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK2 (TRKB) (Mus musculus)
      - Activated NTRK2 signals through FYN (Mus musculus)
        
        NTRK2 activates RAC1 (Mus musculus)
        
        DOCK3 activates RAC1 (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
      - VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
      - p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase cycle (Mus musculus)
      - RAC1 GTPase cycle (Mus musculus)
        
        RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
        
        RAC1 GDIs block activation of RAC1 (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)
        
        RAC1 GEFs activate RAC1 (Mus musculus)
        
        Rac1:GDP [plasma membrane] (Mus musculus)