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What is Reactome ?
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Rac1-GTP [cytosol]
Stable Identifier
R-MMU-421103
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPH-ephrin mediated repulsion of cells (Mus musculus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
Activation of Rac1 by VAV2 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Interaction of PAK1 with Rac1-GTP (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
pPAK1:Rac1-GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Netrin-1 signaling (Mus musculus)
DCC mediated attractive signaling (Mus musculus)
Activation of Rac1 (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
DSCAM interactions (Mus musculus)
Activation of JNK by DSCAM (Mus musculus)
DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane] (Mus musculus)
p-S144-PAK1:RAC1:GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Activation of p38MAPK by DSCAM (Mus musculus)
DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane] (Mus musculus)
p-S144-PAK1:RAC1:GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)
DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane] (Mus musculus)
p-S144-PAK1:RAC1:GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-S144-PAK1:RAC1:GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Semaphorin interactions (Mus musculus)
Sema3A PAK dependent Axon repulsion (Mus musculus)
Activation of PAK by Rac1 (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Phosphorylation of LIMK-1 by PAK (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Sema4D in semaphorin signaling (Mus musculus)
Sema4D mediated inhibition of cell attachment and migration (Mus musculus)
Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Activation of Rac1 by pVav1 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Activation of RAC1 by VAV2/3 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Activation of RAC1 by VAV (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
ABL phosphorylates WAVEs (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Activation of RAC1 by VAV (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Autophosphorylation of PAK1 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK1 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-ERK phosphorylates WAVEs and ABI (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1,RAC2,RHOG activate PI3K (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Mus musculus)
RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
Activation of RAC1 by the PXN:CRK complex (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by MET (Mus musculus)
MET promotes cell motility (Mus musculus)
MET activates RAP1 and RAC1 (Mus musculus)
DOCK7 activates RAC1 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK2 (TRKB) (Mus musculus)
Activated NTRK2 signals through FYN (Mus musculus)
NTRK2 activates RAC1 (Mus musculus)
DOCK3 activates RAC1 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Activation of RAC1 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
PAK1-3 autophosphorylates (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
PAK1-3 dimer disassociates (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1 binds PAK1-3 (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate Formins (Mus musculus)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Mus musculus)
RAC1:GTP:FMNL1 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Mus musculus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Mus musculus)
RAC1:GTP:FMNL1 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Mus musculus)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Mus musculus)
RAC1:GTP:FMNL1 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHO GTPases Activate NADPH Oxidases (Mus musculus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
NOX1 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
NOX3 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP binds NOX1 complex (Mus musculus)
NOX1 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP binds NOX3 complex (Mus musculus)
NOX3 complex:RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHO GTPases Activate WASPs and WAVEs (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
ABL phosphorylates WAVEs (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-ERK phosphorylates WAVEs and ABI (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHO GTPases activate CIT (Mus musculus)
Activated CIT binds KIF14 and PRC1 (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT:KIF14:PRC1 [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CIT-3 binds DLG4 (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Mus musculus)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHO GTPases activate IQGAPs (Mus musculus)
GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
IQGAP1 binds CLIP1 and microtubules (Mus musculus)
RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1,CDC42:GTP:IQGAP1:CLIP1:microtubule [plasma membrane] (Mus musculus)
RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
IQGAPs bind CALM1 (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Mus musculus)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RHO GTPases activate PAKs (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK1 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK2 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK3 (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
Rac1-GTP [cytosol] (Mus musculus)
Participants
components
GTP [cytosol]
Rac1 [plasma membrane] (Mus musculus)
Participant Of
hasComponent
NOX1 complex:RAC1:GTP [plasma membrane]
NOX2 complex:RAC1:GTP [plasma membrane]
NOX3 complex:RAC1:GTP [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane]
p-S144-PAK1:RAC1:GTP [cytosol]
p-VAV family:PIP3:RAC1:GTP [plasma membrane]
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
pPAK1:Rac1-GTP [cytosol]
RAC1:GTP:FMNL1 [plasma membrane]
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane]
Sema3A:pPlexin-A1:Neuropilin-1:Fes:Rac1-GTP [plasma membrane]
Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
output
Activation of RAC1 by CRKII:DOCK180:ELMO
Activation of Rac1 by FARP2
Activation of Rac1 by pVav1
Activation of RAC1 by the PXN:CRK complex
Activation of RAC1 by VAV
Activation of Rac1 by VAV2
Activation of RAC1 by VAV2/3
Activation of RAC1
DOCK180:ELMO exchanges GTP for GDP, activating RAC1
DOCK3 activates RAC1
DOCK7 activates RAC1
p-TIAM1 exchanges GTP for GDP on RAC1, activating it
TIAM1 exchanges GTP for GDP on RAC1, activating it
VAV exchanges GTP for GDP on RAC1, activating it
input
Active Rac1 interacts with Plexin-B1:Sema4D
Interaction of PAK1 with Rac1-GTP
NADPH oxidase 2 (NOX2) complex binds RAC1
Rac1 binds plexin-1
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
RAC1:GTP binds NOX1 complex
RAC1:GTP binds NOX3 complex
hasMember
CDC42:GTP, RAC1:GTP [plasma membrane]
RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane]
Inferred From
RAC1:GTP [plasma membrane] (Homo sapiens)
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