Unc5h1 binds NRAGE

Stable Identifier
R-MMU-418871
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unc5h1 binds NRAGE
The neurotrophin receptor-interacting melanoma-associated antigen (MAGE) homologue, NRAGE, known to be a regulator of apoptosis, has been identified as a specific binding partner of UNC5H1. NRAGE utilizes two mechanisms to induce UNC5H1mediated apoptosis in cells: first, through the degradation of the caspase inhibitor X-chromosome-linked inhibitor of apoptosis protein (XIAP), and second, through the activation of the proapoptotic c-JUN N-terminal kinase (JNK) signaling pathway.
Literature References
PubMed ID Title Journal Year
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
17449433 Dependence receptors: when apoptosis controls tumor progression

Mehlen, P, Bernet, A

Bull Cancer 2007
12598531 UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE

Strickland, P, Hinck, L, Williams, ME, Watanabe, K

J Biol Chem 2003
Participants
Input
Output
Orthologous Events
UNC5A binds NRAGE (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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