Shp2 binds pUnc5C

Stable Identifier
R-MMU-418862
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Shp2 binds pUnc5C

PTPN11 (SHP2) is recruited to the phosphorylated UNC5C receptor after netrin-1 (NTN1) stimulation, in a fashion that requires binding of the PTPN11 SH2 domains to the Tyr568 (Y568) phosphorylated motif. The functional significance of the UNC5C- PTPN11 interaction has not been reported. PTPN11 might negatively regulate tyrosine phosphorylation of UNC5C receptor, facilitating resensitization of the receptor to the netrin-1 signal.

Literature References
PubMed ID Title Journal Year
11533026 Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain

Tong, J, Killeen, M, Steven, R, Binns, KL, Culotti, J, Pawson, T

J Biol Chem 2001
17254765 Netrin signaling leading to directed growth cone steering

Round, J, Stein, E

Curr Opin Neurobiol 2007
Participants
Orthologous Events
Authored
Reviewed
Created