Caspase cleavage of Unc5h1

Stable Identifier
R-MMU-418855
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase cleavage of Unc5h1

The UNC5H netrin1 receptors also contain death domains in their intracellular regions and function as dependence receptors. The cleavage site sequence DITD(S) found in UNC5H2 appears to be a classic caspase DXXD site and is conserved in UNC5H1 and UNC5H3 (DVAD(S) and DIID(S), respectively).

Literature References
PubMed ID Title Journal Year
11387206 Netrin-1 acts as a survival factor via its receptors UNC5H and DCC

Llambi, F, Causeret, F, Bloch-Gallego, E, Mehlen, P

EMBO J 2001
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
Participants
Input
Output
Catalyst Activity

aspartic-type endopeptidase activity of Caspase-3 tetramer [cytosol]

Physical Entity
Caspase-3 tetramer [cytosol] (Mus musculus)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
Caspase cleavage of UNC5A (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
Cite Us!