Caspase cleavage of Unc5h2

Stable Identifier
R-MMU-418848
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase cleavage of Unc5h2
The UNC5H family of netrin-1 receptors also contain death domains in their intracellular regions and function as dependence receptors. The cleavage site sequence DITD(S) found in UNC5H2 appears to be a classic caspase DXXD site and is conserved in UNC5H1 and UNC5H3 (DVAD(S) and DIID(S), respectively). UNC5H2, like DCC, is cleaved at Asp412 by caspase-3 or an unknown protease, but in contrast to DCC this results in the release of the death domain from the C-terminal region (Llambi et al. 2001).
Literature References
PubMed ID Title Journal Year
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
11387206 Netrin-1 acts as a survival factor via its receptors UNC5H and DCC

Bloch-Gallego, E, Llambi, F, Mehlen, P, Causeret, F

EMBO J 2001
Participants
Input
Output
Catalyst Activity

cysteine-type endopeptidase activity of unidentified caspase [cytosol]

Physical Entity
unidentified caspase [cytosol] (Mus musculus)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase cleavage of UNC5B (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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