Ephb2 binds p120-RasGAP

Stable Identifier
Reaction [binding]
Mus musculus
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Ephb2 binds p120-RasGAP

In addition to regulating Rho family proteins, the EPH receptors and ephrins (EFNs) also regulate the activity of Ras family proteins. Ras-MAPK pathway is a key regulator of cell proliferation, adhesion and transformation, but can also influence axon guidance (Forcet et al. 2002). EPHB receptors downregulate H-Ras and consequently its downstream effector extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway in neuronal cells (Elowe et al. 2001, Miao et al. 2000). EPHB2 signals through the SH2 domain protein p120-RasGAP (RASA1) to inhibit the Ras-MAPK pathway. p120-RasGAP binds directly through its SH2 domains to the autophosphorylated EPHB2 juxtamembrane region (Holland et al. 1997, Elowe et al. 2001).

Literature References
PubMed ID Title Journal Year
9233798 Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

Holland, SJ, Gale, NW, Gish, GD, Roth, RA, Songyang, Z, Cantley, LC, Henkemeyer, M, Yancopoulos, GD, Pawson, T

EMBO J. 1997
11585923 Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

Elowe, S, Holland, SJ, Kulkarni, S, Pawson, T

Mol. Cell. Biol. 2001
Orthologous Events
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