Reactome | Pik3cd [plasma membrane]

Pik3cd [plasma membrane]

Stable Identifier

R-MMU-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

PIK3CD, O35904

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-stimulation by CD28 (Mus musculus)
      - CD28 dependent PI3K/Akt signaling (Mus musculus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        PI3K binds CD28 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
    - Co-stimulation by ICOS (Mus musculus)
      - PI3K binds ICOS (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
  - Signaling by the B Cell Receptor (BCR) (Mus musculus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
        
        BCAP Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
      - CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
        
        CD19 Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
      - p-CD19:VAV binds PI3K and GRB2 (Mus musculus)
        
        CD19 Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
      - Regulation of signaling by CBL (Mus musculus)
        
        CBL ubiquitinates PI3K (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        BCAP Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        CD19 Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        BCAP Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        CD19 Signalosome [plasma membrane] (Mus musculus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K delta [cytosol] (Mus musculus)
        
        Pik3cd [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:O35904 Pik3cd

Gene Names

Pik3cd

Chain

chain:1-1043

Reference Genes

BioGPS Gene:18707 Pik3cd

KEGG:mmu:18707 Pik3cd

Monarch:18707 Pik3cd

NCBI Gene:18707 Pik3cd

UCSC:O35904 Pik3cd

Reference Transcript

Other Identifiers

103866_at

10518686

1422991_at

1422992_s_at

1446770_at

1453281_at

17433169

18707

4311456

4407184

4434321

4467522

4497832

4532988

4554147

4554622

4556036

4573429

4588416

4604197

4675867

4678970

4752063

4770922

4807633

4830814

4942594

4942610

4982634

4989309

5015561

5081259

5103182

5118339

5160059

5182689

5218981

5232122

5234066

5288477

5290018

5365093

5399797

5406376

5437685

5454376

5467873

5482879

5505098

5523329

5563629

5565634

5587270

92390_at

A_55_P2028263

A_55_P2028268

A_55_P2736754

GE34204

GO:0000166

GO:0001782

GO:0001938

GO:0002250

GO:0002376

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0006629

GO:0006935

GO:0006954

GO:0007166

GO:0010595

GO:0010628

GO:0016301

GO:0016303

GO:0016477

GO:0016740

GO:0022603

GO:0030154

GO:0030335

GO:0033031

GO:0035005

GO:0036092

GO:0038084

GO:0042113

GO:0043491

GO:0045087

GO:0045766

GO:0046854

GO:0046934

GO:0048015

GO:0048870

GO:0048872

GO:0050832

GO:0051094

GO:0051240

GO:0098542

GO:1905278

GO:2000026

ILMN_1247619

ILMN_2655112

ILMN_3052174

ILMN_3128616

mMC022985

mMC025136

Participates

as a component of

Other forms of this molecule

Pik3cd [cytosol]

Inferred From

PIK3CD [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001157524.1, XP_006538715.1

ENSEMBL

ENSMUSG00000039936, ENSMUST00000105689, ENSMUSP00000101314

ZINC target

O35904

PRO

O35904

MGI

1098211

PDB

2WXF, 5L72, 2WXO, 5T27, 5T28, 2X38, 2WXG, 5I4U, 2WXP, 5T2G, 2WXH, 2WXQ, 5NGB, 2WXR, 2WXI, 5T2B, 2WXJ, 5T2I, 5NCZ, 6EYZ, 5T7F, 5O83, 6MUL, 5NCY, 6MUM, 2WXK, 4XE0, 5T2L, 4V0I, 6DGT, 2WXL, 5T2D, 5T8I, 5IS5, 5AE9, 2WXM, 4AJW, 6GY0, 5T2M, 5I6U, 2WXN, 5AE8, 6EZ6, 6HI9

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