Reactome | Chrm2 [plasma membrane]

Chrm2 [plasma membrane]

Stable Identifier

R-MMU-390654

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

CHRM2, Q9ERZ4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Muscarinic acetylcholine receptors (Mus musculus)
        
        CHRM2 binds CHRM2 antagonists (Mus musculus)
        
        CHRM2:CHRM2 antagonists [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        CHRM2,4 bind acetylcholine (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - ARRB bind GPCRs (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        Chrm2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9ERZ4

Gene Names

Chrm2

Reference Genes

BioGPS Gene:243764 Chrm2

ENSEMBL:ENSMUSG00000045613

ENSEMBL:ENSMUSG00000045613.10 Chrm2

KEGG Gene (Mus musculus):243764 Chrm2

Monarch:243764 Chrm2

NCBI Gene:243764 Chrm2

UCSC:Q9ERZ4 Chrm2

Reference Transcript

Other Identifiers

10537298

138097_f_at

17457310

243764

4349702

4394534

4425956

4462455

4500575

4848663

5014349

5592847

A_51_P292341

A_55_P2055284

GE1389348

GE1549345

GO:0003012

GO:0003013

GO:0004930

GO:0004993

GO:0005886

GO:0006940

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0032279

GO:0032280

GO:0042734

GO:0043025

GO:0043679

GO:0045202

GO:0045211

GO:0060089

GO:0098664

GO:0098978

GO:0098981

GO:0099171

GO:1990763

ILMN_1212801

ILMN_2766727

ILMN_2971508

mMC014796

mMC019695

Participates

as a member of

as an input of

CHRM2 binds CHRM2 antagonists (Mus musculus)

as a component of

CHRM2:CHRM2 antagonists [plasma membrane] (Mus musculus)

Other forms of this molecule

Chrm2 [clathrin-coated endocytic vesicle membrane]

Inferred From

CHRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_987076.2, XP_006506199.1

ZINC - Metabolites

ACM2_MOUSE

ZINC - World Drugs

ACM2_MOUSE

ZINC - FDA approved

ACM2_MOUSE

ZINC - Substances

ACM2_MOUSE

ZINC - Biogenic

ACM2_MOUSE

Ensembl

ENSMUSP00000130874, ENSMUST00000172278, ENSMUSG00000045613

ZINC target

Q9ERZ4

PRO

Q9ERZ4

MGI

88397

ZINC - Predictions - Purchasable

ACM2_MOUSE

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