Reactome | Cbx4 [nucleoplasm]

Cbx4 [nucleoplasm]

Stable Identifier

R-MMU-389118

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CBX4, O55187

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Mus musculus)
        
        RUNX1 binds PRC1 complexes (Mus musculus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx4 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx4 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx4 [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx4 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O55187 Cbx4

Gene Names

Cbx4, Pc2

Chain

chain:1-551

Reference Genes

BioGPS Gene:12418 Cbx4

ENSEMBL:ENSMUSG00000039989 Cbx4

KEGG Gene (Mus musculus):12418 Cbx4

Monarch:12418 Cbx4

NCBI Gene:12418 Cbx4

UCSC:O55187 Cbx4

Reference Transcript

RefSeq:NM_007625.2 Cbx4

Other Identifiers

10393620

12418

138110_at

1419583_at

1440479_at

17272857

4307458

4436504

4618186

4752528

4880855

4909797

4939849

5018400

5064370

5074068

5098639

5219090

5255094

5420377

5489649

93697_at

A_51_P133582

GE1511012

GE34817

GO:0008150

GO:0009058

GO:0034641

GO:0045892

ILMN_2690038

mMC018127

Participates

as a member of

as a component of

SUMO1:BMI1:PRC1 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Cbx4 [nucleoplasm]

Inferred From

CBX4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_031651.2

Ensembl

ENSMUST00000026665, ENSMUSP00000026665, ENSMUSG00000039989

PRO

O55187

MGI

1195985

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