Reactome | Cbx8 [nucleoplasm]

Cbx8 [nucleoplasm]

Stable Identifier

R-MMU-389117

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CBX8, Q9QXV1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Mus musculus)
        
        RUNX1 binds PRC1 complexes (Mus musculus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx8 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx8 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx8 [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC1.4 [nucleoplasm] (Mus musculus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)
        
        Cbx8 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QXV1

Gene Names

Cbx8

Reference Genes

BioGPS Gene:30951 Cbx8

ENSEMBL:ENSMUSG00000025578

ENSEMBL:ENSMUSG00000025578 Cbx8

KEGG Gene (Mus musculus):30951 Cbx8

Monarch:30951 Cbx8

NCBI Gene:30951 Cbx8

UCSC:Q9QXV1 Cbx8

Reference Transcript

RefSeq:NM_013926.1 Cbx8

Other Identifiers

10393614

1419198_at

1419199_at

17272845

30951

4475126

4697739

4706898

4853635

4938653

5309593

5505973

5517742

A_52_P229997

A_52_P89273

GE36568

ILMN_1232016

mMC024451

Participates

as a component of

as a member of

CBX2,CBX4,CBX8 [nucleoplasm] (Mus musculus)

Inferred From

CBX8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_038954.1

Ensembl

ENSMUSP00000026663, ENSMUSG00000025578, ENSMUST00000026663

PRO

Q9QXV1

MGI

1353589

PDB

2DNV

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23798 Pcgf2	2	Pcgf2 [nucleoplasm] (R-MMU-5619463) Pcgf2 [nucleoplasm] (R-MMU-389115)	0.527	3

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