Reactome | Pomc [extracellular region]

Pomc [extracellular region]

Stable Identifier

R-MMU-388607

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

POMC(138-176), P01193

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        POMC(138-176):MC2R [plasma membrane] (Mus musculus)
        
        Pomc [extracellular region] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        POMC(138-176):MC2R [plasma membrane] (Mus musculus)
        
        Pomc [extracellular region] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Peptide ligand-binding receptors (Mus musculus)
        
        POMC(138-176) binds MC2R (Mus musculus)
        
        POMC(138-176):MC2R [plasma membrane] (Mus musculus)
        
        Pomc [extracellular region] (Mus musculus)
        
        Pomc [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P01193 Pomc

Gene Names

Pomc, Pomc1

Chain

signal peptide:1-26, peptide:27-100, peptide:77-87, propeptide:103-121, peptide:124-162, peptide:124-136, peptide:142-162, peptide:165-235, peptide:165-202, peptide:185-202, peptide:205-235, peptide:205-209

Reference Genes

BioGPS Gene:18976 Pomc

ENSEMBL:ENSMUSG00000020660.7 Pomc

KEGG Gene (Mus musculus):18976 Pomc

Monarch:18976 Pomc

NCBI Gene:18976 Pomc

UCSC:P01193 Pomc

Reference Transcript

Other Identifiers

10394240

1433800_a_at

1455858_x_at

17273694

18976

4305734

4363818

4408458

4431039

4500197

4579217

5413083

5539571

94026_at

A_52_P671543

GO:0001664

GO:0002376

GO:0003013

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005777

GO:0005782

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0007165

GO:0007218

GO:0007267

GO:0008217

GO:0019722

GO:0023052

GO:0030141

GO:0031410

GO:0031640

GO:0031781

GO:0031782

GO:0032098

GO:0032720

GO:0033059

GO:0035821

GO:0042593

GO:0043226

GO:0043950

GO:0045944

GO:0048018

GO:0050886

GO:0061844

GO:0070873

GO:0070965

GO:0070996

GO:0098542

GO:0098772

GO:0140668

GO:1990680

GO:2000852

ILMN_2481962

ILMN_2745802

Msa.2089.0_s_at

mMC003727

Participates

as an input of

POMC(138-176) binds MC2R (Mus musculus)

as a component of

POMC(138-176):MC2R [plasma membrane] (Mus musculus)

Other forms of this molecule

Pomc [secretory granule lumen]

Pomc [cytosol]

Pomc(124-136) [extracellular region]

Pomc [extracellular region]

Inferred From

POMC(138-176) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001265511.1, NP_032921.1, NP_001265513.1, NP_001265512.1, NP_001265510.1

Ensembl

ENSMUST00000219543, ENSMUSP00000151504, ENSMUST00000218089, ENSMUSP00000151367, ENSMUST00000020990, ENSMUSP00000020990, ENSMUSG00000020660

PRO

P01193

MGI

97742