Ccs transfers Cu to Sod1

Stable Identifier
R-MMU-3780963
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Ccs transfers Cu to Sod1

As inferred from the cytosolic reaction, copper chaperone of superoxide dismutase (Ccs) in the mitochondrial intermembrane space transfers a copper(I) atom to a Sod1 monomer that already contains a Zn atom. After initial heterodimerization between Sod1 and Ccs, the copper atom is transferred, intramolecular cysteine disulfide bonds are formed in Sod1, and Sod1 dimerizes.

Literature References
PubMed ID Title Journal Year
18703498 Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

Kawamata, H, Manfredi, G

Hum. Mol. Genet. 2008
Participants
Orthologous Events
Authored
Reviewed
Created
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