Sod1 apoenzyme binds Ccs

Stable Identifier
R-MMU-3780959
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Sod1 apoenzyme binds Ccs

As inferred from the cytosolic reaction, copper chaperone of superoxide dismutase (Ccs) in the mitochondrial intermembrane space transfers a copper(I) atom to a Sod1 monomer that already contains a Zn atom. The reaction proceeds by a two step mechanism in which Sod1 first forms heterodimers with Ccs. The amounts of Ccs and Sod1 imported to the intermembrane space appear to be regulated by the concentration of oxygen (Kawawata and Manfredi 2008).

Literature References
PubMed ID Title Journal Year
18703498 Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

Kawamata, H, Manfredi, G

Hum. Mol. Genet. 2008
Participants
Orthologous Events
Authored
Reviewed
Created