Reactome | Ska2 [cytosol]

Ska2 [cytosol]

Stable Identifier

R-MMU-376231

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SKA2, Q9CR46

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Ska2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CR46

Gene Names

Ska2

Reference Genes

BioGPS Gene:66140 Ska2

ENSEMBL:ENSMUSG00000020492

ENSEMBL:ENSMUSG00000020492.12 Ska2

KEGG Gene (Mus musculus):66140 Ska2

Monarch:66140 Ska2

NCBI Gene:66140 Ska2

UCSC:Q9CR46 Ska2

Reference Transcript

RefSeq:NM_025377.3 Ska2

Other Identifiers

10379989

115898_at

1423440_at

1437480_at

17254670

4314789

4322142

4456525

4546505

4684004

4687657

4824829

4916703

5103552

5300105

5375198

5414562

5502206

5536181

5602525

66140

A_51_P237512

C78640_rc_at

GE40713

GO:0000278

GO:0000775

GO:0000776

GO:0000940

GO:0005694

GO:0005737

GO:0005819

GO:0005856

GO:0005874

GO:0005876

GO:0007010

GO:0007049

GO:0007059

GO:0008017

GO:0008092

GO:0031110

GO:0043226

GO:0051301

GO:0051315

GO:0140014

ILMN_2645490

ILMN_2665957

ILMN_2789047

mMC007324

mMC023391

mMR027093

Participates

as a component of

Kinetochore [cytosol] (Mus musculus)

Inferred From

SKA2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_079653.1

Ensembl

ENSMUSP00000020794, ENSMUSG00000020492, ENSMUST00000020794

PRO

Q9CR46

MGI

1913390

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