Reactome | Spc25 [cytosol]

Spc25 [cytosol]

Stable Identifier

R-MMU-375307

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SPC25, Q3UA16

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Spc25 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3UA16

Gene Names

Spc25

Reference Genes

BioGPS Gene:66442 Spc25

ENSEMBL:ENSMUSG00000005233

ENSEMBL:ENSMUSG00000005233.17 Spc25

KEGG Gene (Mus musculus):66442 Spc25

Monarch:66442 Spc25

NCBI Gene:66442 Spc25

UCSC:Q3UA16 Spc25

Reference Transcript

Other Identifiers

10483401

107081_at

1424118_a_at

17386161

4348419

4531790

4566240

4724538

4770471

4795193

4925849

4959242

5007609

5022759

5120368

5321770

5505567

66442

A_55_P1965154

GE39541

GO:0000278

GO:0000775

GO:0000776

GO:0003674

GO:0005634

GO:0005694

GO:0005829

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007094

GO:0008608

GO:0023052

GO:0031262

GO:0043226

GO:0051301

GO:0140014

ILMN_1255960

ILMN_2901180

mMC009891

Participates

as a component of

NDC80 complex [cytosol] (Mus musculus)

Inferred From

SPC25 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_079841.1, NP_001186052.1, NP_001292729.1, XP_006500066.1, NP_001186053.1

Ensembl

ENSMUST00000112320, ENSMUSP00000005365, ENSMUST00000005365, ENSMUST00000167875, ENSMUSP00000107939, ENSMUSP00000128039, ENSMUSG00000005233

PRO

Q3UA16

MGI

1913692

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