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Wnt3a [extracellular region]
Stable Identifier
R-MMU-3247784
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
N4GlycoAsn-PalmS WNT3A, P27467
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Canonical WNT signaling through the atypical receptor RYK (Mus musculus)
RYK-binding WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
RYK:WNTs [plasma membrane] (Mus musculus)
RYK-binding WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Mus musculus)
Beta-catenin is released from the destruction complex (Mus musculus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Mus musculus)
WNT:FZD:LRP5/6 [plasma membrane] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Mus musculus)
WNT:FZD:LRP5/6 [plasma membrane] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Mus musculus)
WNT:FZD:LRP5/6 [plasma membrane] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
Regulation of FZD by ubiquitination (Mus musculus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
WNT ligand biogenesis and trafficking (Mus musculus)
secretion of WNT ligands (Mus musculus)
WNTs [extracellular region] (Mus musculus)
Wnt3a [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P27467 Wnt3a
Gene Names
Wnt3a, Wnt-3a
Chain
signal peptide:1-18, chain:19-352
Reference Genes
BioGPS Gene:22416 Wnt3a
ENSEMBL:ENSMUSG00000009900 Wnt3a
KEGG Gene (Mus musculus):22416 Wnt3a
Monarch:22416 Wnt3a
NCBI Gene:22416 Wnt3a
UCSC:P27467 Wnt3a
Reference Transcript
RefSeq:NM_009522.2 Wnt3a
Other Identifiers
102667_at
10386376
1422093_at
17263388
22416
4431829
4911428
4942281
5011097
5023545
5101253
5398124
A_51_P210970
A_55_P2067649
GE36453
GO:0001649
GO:0001701
GO:0001756
GO:0001819
GO:0001934
GO:0001947
GO:0002092
GO:0002376
GO:0003136
GO:0003713
GO:0005102
GO:0005109
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0006351
GO:0006355
GO:0006366
GO:0007010
GO:0007155
GO:0007165
GO:0007267
GO:0007275
GO:0007368
GO:0007409
GO:0007411
GO:0007498
GO:0008104
GO:0008283
GO:0008284
GO:0009887
GO:0009952
GO:0009986
GO:0010387
GO:0010468
GO:0010628
GO:0010977
GO:0016055
GO:0016192
GO:0019904
GO:0021527
GO:0021766
GO:0021846
GO:0021874
GO:0021904
GO:0022008
GO:0023052
GO:0030097
GO:0030154
GO:0030168
GO:0030182
GO:0030198
GO:0030509
GO:0030879
GO:0030890
GO:0030901
GO:0032092
GO:0032991
GO:0033138
GO:0033278
GO:0034330
GO:0035914
GO:0036211
GO:0036342
GO:0039706
GO:0042060
GO:0042100
GO:0042472
GO:0042802
GO:0043226
GO:0043280
GO:0045165
GO:0045202
GO:0045444
GO:0045445
GO:0045595
GO:0045599
GO:0045860
GO:0045893
GO:0045944
GO:0048018
GO:0048103
GO:0048337
GO:0048343
GO:0048643
GO:0048697
GO:0048843
GO:0048856
GO:0050768
GO:0050770
GO:0050804
GO:0050807
GO:0051091
GO:0055085
GO:0060070
GO:0060923
GO:0061098
GO:0061184
GO:0061317
GO:0062009
GO:0065003
GO:0070507
GO:0070527
GO:0071542
GO:0072659
GO:0090245
GO:0090263
GO:0090676
GO:0098772
GO:0098978
GO:0099527
GO:1901215
GO:1903078
GO:1904339
GO:1905606
GO:1990851
GO:1990909
GO:2000049
GO:2000081
GO:2000179
GO:2000347
GO:2000727
GO:2001141
ILMN_1220516
X56842_s_at
mMC012243
Participates
as a component of
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Mus musculus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Mus musculus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Mus musculus)
as a member of
RYK-binding WNTs [extracellular region] (Mus musculus)
canonical WNTs [extracellular region] (Mus musculus)
WNTs [extracellular region] (Mus musculus)
Other forms of this molecule
Wnt3a [extracellular exosome]
Wnt3a [endocytic vesicle membrane]
N4GlycoAsn-PalmS Wnt3a [extracellular region]
Wnt3a [extracellular region]
Wnt3a [early endosome membrane]
N4GlycoAsn-PalmS Wnt3a [endoplasmic reticulum lumen]
N-glycosyl Wnt3a [endoplasmic reticulum lumen]
Wnt3a [endoplasmic reticulum lumen]
Wnt3a [endoplasmic reticulum lumen]
Wnt3a [Golgi lumen]
Wnt3a [plasma membrane]
Inferred From
N4GlycoAsn-PalmS WNT3A [extracellular region]
(Homo sapiens)
Modified Residues
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
O-palmitoleyl-L-serine at 209
Coordinate
209
PsiMod Name
O-palmitoleyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.
Cross References
RefSeq
NP_033548.1
ZINC - Substances
WNT3A_MOUSE
ZINC target
P27467
Ensembl
ENSMUSG00000009900
,
ENSMUST00000010044
,
ENSMUSP00000010044
PRO
P27467
MGI
98956
ZINC - Predictions - Purchasable
WNT3A_MOUSE
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61091 Fzd8
4
ub-FZD8 [plasma membrane]
(R-MMU-4641183)
mFz8CRD [extracellular region]
(R-MMU-1458870)
FZD8 [plasma membrane]
(R-MMU-443947)
Fzd8 [plasma membrane]
(R-MMU-517517)
0.825
7
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.713
4
UniProt:Q9Y5W5 WIF1
1
WIF1 [extracellular region]
(R-HSA-3769320)
0.676
8
UniProt:P43652 AFAM
0.602
3
UniProt:A6NFA1 TIKI2
0.544
2
UniProt:E9Q612 PTPRO
0.524
2
UniProt:G3MYZ3 AFAM
0.499
3
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