Reactome | Glycosylation of mouse WNTs

Glycosylation of mouse WNTs

Stable Identifier

R-MMU-3238692

Type

Reaction [omitted]

Species

Mus musculus

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

WNTs contain a N-terminal signal peptide and undergo N-linked glycosylation (Smolich et al, 1993; Willert et al, 2003; Komekado et al, 2006; Kurayohsi et al, 2007). Mutation of identified asparagine residues in WNT3A and WNT5A blocks glycosylation and secretion of the ligands (Komekado et al, 2006; Kuroyoshi et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
8167409	Wnt family proteins are secreted and associated with the cell surface McMahon, JA, Papkoff, J, McMahon, AP, Smolich, BD	Mol. Biol. Cell	1993
17117926	Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling Izumi, S, Kurayoshi, M, Kikuchi, A, Yamamoto, H	Biochem. J.	2007
12717451	Wnt proteins are lipid-modified and can act as stem cell growth factors Reya, T, Weissman, IL, Brown, JD, Yates, JR, Duncan, AW, Danenberg, E, Nusse, R, Willert, K	Nature	2003
17397399	Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a Kikuchi, A, Komekado, H, Yamamoto, H, Chiba, T	Genes Cells	2007