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SMAD2 [cytosol]
Stable Identifier
R-MMU-3006353
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q62432
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by Activin (Mus musculus)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
Degradation of ubiquitinated SMAD2 (Mus musculus)
Ub-SMAD2 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
SMAD2/3:PMEPA1 [plasma membrane] (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
SMURF2 binds SMAD2 (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
SMURF2 ubiquitinates SMAD2 (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Ub-SMAD2 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
SMAD2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62432 Smad2
Gene Names
Smad2, Madh2, Madr2
Chain
initiator methionine:, chain:2-467
Reference Genes
BioGPS Gene:17126 Smad2
ENSEMBL:ENSMUSG00000024563.17 Smad2
KEGG Gene (Mus musculus):17126 Smad2
Monarch:17126 Smad2
NCBI Gene:17126 Smad2
UCSC:Q62432 Smad2
Reference Transcript
RefSeq:NM_001311070.1 Smad2
RefSeq:NM_010754.5 Smad2
RefSeq:XM_017317842.1 Smad2
RefSeq:XM_006525699.2 Smad2
RefSeq:NM_001252481.1 Smad2
Other Identifiers
104536_at
10456764
1420634_a_at
1442062_at
1444994_at
17126
17351886
4316916
4359279
4379980
4410713
4411868
4418351
4423474
4459260
4478987
4529194
4582989
4660123
4691924
4766898
4788832
4995549
5012079
5014780
5137847
5147445
5198549
5259156
5272466
5429284
5492173
5554801
5603093
A_52_P397280
A_55_P1999710
A_55_P2340735
A_66_P116808
GE1447599
GE35709
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003140
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0007179
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008285
GO:0009653
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010628
GO:0010629
GO:0010718
GO:0017015
GO:0019902
GO:0023019
GO:0023052
GO:0030073
GO:0030154
GO:0030324
GO:0030325
GO:0030513
GO:0031016
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071144
GO:0071895
GO:0097718
GO:0140110
GO:0140297
ILMN_1228414
ILMN_2462387
ILMN_2483875
af005743_s_at
mMC003622
mMC005128
mMC007220
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD2,3 [cytosol] (Mus musculus)
as a component of
Ub-SMAD2 [cytosol] (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
as an input of
SMURF2 binds SMAD2 (Mus musculus)
Other forms of this molecule
Ub-SMAD2 [cytosol]
phospho-p-S250-SMAD2 [cytosol]
SMAD2 [nucleoplasm]
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
phospho-p-S465,S467-SMAD2 [cytosol]
p-S465,467-Smad2 [nucleoplasm]
Inferred From
SMAD2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017173331.1
,
NP_001239410.1
,
XP_006525762.1
,
NP_034884.2
,
NP_001297999.1
Ensembl
ENSMUSP00000130115
,
ENSMUST00000091831
,
ENSMUSG00000024563
,
ENSMUSP00000025453
,
ENSMUSP00000089439
,
ENSMUST00000168423
,
ENSMUST00000025453
PRO
Q62432
MGI
108051
HMDB Protein
HMDBP14505
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