Reactome | Efna2 [plasma membrane]

Efna2 [plasma membrane]

Stable Identifier

R-MMU-2682320

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

EFNA2, P52801

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - EPH-Ephrin signaling (Mus musculus)
      - EPH receptors autophosphorylate (Mus musculus)
        
        EPH-ephrin oligomers [plasma membrane] (Mus musculus)
        
        EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
      - EPH-ephrin mediated repulsion of cells (Mus musculus)
        
        EPHA binds TIAM1 (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        SFKs phosphorylate VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        p-EPHs bind VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
      - EPH:EFN dimers tetramerise (Mus musculus)
        
        EPH-EFN dimers [plasma membrane] (Mus musculus)
        
        EPHA:EFNA dimers [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
      - EPH:EFN tetramers oligomerise (Mus musculus)
        
        EPH-EFN dimers [plasma membrane] (Mus musculus)
        
        EPHA:EFNA dimers [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EPH-ephrin oligomers [plasma membrane] (Mus musculus)
        
        EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
      - EPHA-mediated growth cone collapse (Mus musculus)
        
        NGEF exchanges GTP for GDP on RHOA (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Mus musculus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Mus musculus)
        
        p-EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
      - EPHAs bind EFNAs (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs [plasma membrane] (Mus musculus)
        
        EFNAs [plasma membrane] (Mus musculus)
        
        Efna2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P52801 Efna2

Gene Names

Efna2, Elf1, Epl6, Eplg6, Lerk6

Chain

signal peptide:1-20, chain:21-184, propeptide:185-209

Reference Genes

BioGPS Gene:13637 Efna2

ENSEMBL:ENSMUSG00000003070.7 Efna2

KEGG Gene (Mus musculus):13637 Efna2

Monarch:13637 Efna2

NCBI Gene:13637 Efna2

UCSC:P52801 Efna2

Reference Transcript

RefSeq:NM_007909.3 Efna2

Other Identifiers

102869_at

10364722

13637

1417521_at

1444606_at

17235243

4329105

4347213

4686406

4825712

5172167

5192469

A_51_P352850

A_55_P2049687

GE34992

GO:0005515

GO:0005886

GO:0007411

GO:0016020

GO:0021772

GO:0023052

GO:0030154

GO:0030316

GO:0031594

GO:0043204

GO:0046849

GO:0046875

GO:0048013

GO:0048856

GO:0098552

ILMN_2647949

mMC022532

u14752_s_at

Participates

as a member of

EFNAs [plasma membrane] (Mus musculus)

Other forms of this molecule

Efna2 (21-?) [plasma membrane]

Efna2 (?-184) [plasma membrane]

Efna2 [plasma membrane]

Inferred From

EFNA2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_031935.3

Ensembl

ENSMUSP00000003154, ENSMUSG00000003070, ENSMUST00000003154

PRO

P52801

MGI

102707

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