Reactome | Phosphorylated Lep:Lepr:Jak2:Sh2b1 Binds Irs1/2

Stable Identifier

R-MMU-2671841

Type

Reaction [binding]

Species

Mus musculus

Compartment

plasma membrane, cytosol

General

SBML | | PDF

SVG | | PPTX | SBGN

Irs1/2 binds Sh2b1 within the Lep:Lepr:Jak2:Sh2b1 complex. This brings Irs1/2 into proximity with the Jak2 kinase.

Literature References

PubMed ID	Title	Journal	Year
15316008	SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin Duan, C, Li, M, Rui, L	J Biol Chem	2004
10377387	Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2 Carter-Su, C, Rui, L	Proc. Natl. Acad. Sci. U.S.A.	1999

Participants

Input

Output

Orthologous Events

Authored

May, B (2012-11-24)

Reviewed

Scherer, T (2013-08-31)

Gonzalez-Perez, RR (2013-10-26)

Created

May, B (2012-11-26)

Cite Us!