Jak2 Phosphorylates Irs1/2 in Response to Leptin

Stable Identifier
R-MMU-2671830
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Jak2 Phosphorylates Irs1/2 in Response to Leptin
Jak2 in the Lep:Lepr:Jak2:Sh2b1:Irs1/2 complex phosphorylates Irs1/2. Phosphorylated Irs1/2 activates PI3K, AKT, and mTOR signaling pathways.
Literature References
PubMed ID Title Journal Year
9389430 Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

Capp, E, Kellerer, M, Koch, M, Metzinger, E, Mushack, J, Häring, HU

Diabetologia 1997
Participants
Catalyst Activity

protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Sh2b1:Irs1,2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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