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DISC [plasma membrane]
Stable Identifier
R-MMU-2671814
Type
Set [DefinedSet]
Species
Mus musculus
Compartment
cytosol
,
plasma membrane
Synonyms
death-inducing signaling complex
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
Participants
members
FASL:FAS Receptor Trimer:FADD [plasma membrane]
(Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane]
(Mus musculus)
Participates
as a component of
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
Inferred From
DISC [plasma membrane]
(Homo sapiens)
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