Collagen type XXIII ectodomain shedding

Stable Identifier
R-MMU-2484926
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Collagen type XXIII ectodomain shedding
Collagen type XXIII is a type II transmembrane collagen with a relatively small ectodomain. It exists in a membrane-bound form and a shed form that is cleaved by furin (Veit et al. 2007). Both forms can bind alpha2beta1 integrin via the ectodomain, stimulating the formation of focal adhesion plaques (Veit et al. 2011).
Literature References
PubMed ID Title Journal Year
17627939 Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment

Bruckner-Tuderman, L, Koch, M, Kutsch, S, Franzke, CW, Gordon, MK, Zimina, EP, Veit, G, Siebolds, U

J Biol Chem 2007
Participants
Catalyst Activity

serine-type endopeptidase activity of Furin [extracellular region]

Orthologous Events
Authored
Reviewed
Created
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