Reactome | 2xAcK-SMC3 [chromosome]

2xAcK-SMC3 [chromosome]

Stable Identifier

R-MMU-2468146

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

chromosome

Synonyms

Q9CW03

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin Complex [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin Complex [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin Complex [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)
        
        Resolution of sister chromatids (Mus musculus)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)
  - S Phase (Mus musculus)
    - Establishment of Sister Chromatid Cohesion (Mus musculus)
      - CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Mus musculus)
        
        Ac-Cohesin Complex [chromosome] (Mus musculus)
        
        2xAcK-SMC3 [chromosome] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CW03 Smc3

Gene Names

Smc3, Bam, Bmh, Cspg6, Mmip1, Smc3l1, Smcd

Chain

chain:1-1217

Reference Genes

BioGPS Gene:13006 Smc3

ENSEMBL:ENSMUSG00000024974 Smc3

KEGG Gene (Mus musculus):13006 Smc3

Monarch:13006 Smc3

NCBI Gene:13006 Smc3

UCSC:Q9CW03 Smc3

Reference Transcript

RefSeq:NM_007790.3 Smc3

Other Identifiers

102853_at

10463951

13006

1450950_at

1450951_at

17360355

4322018

4332612

4353195

4385679

4394119

4417602

4419013

4432079

4435893

4470901

4502181

4524778

4535288

4593327

4643859

4679392

4680450

4688371

4785933

4850497

4850925

4853509

4908900

4933704

4936353

4959666

4991395

5006690

5045435

5065864

5080803

5139926

5176574

5182748

5184474

5292062

5350594

5486703

5582003

5594186

A_52_P138002

A_55_P2130610

A_66_P111148

GE34906

GO:0000166

GO:0000228

GO:0000278

GO:0000775

GO:0000785

GO:0000795

GO:0000800

GO:0003677

GO:0003682

GO:0003690

GO:0003824

GO:0005515

GO:0005524

GO:0005604

GO:0005634

GO:0005654

GO:0005694

GO:0005856

GO:0006260

GO:0006275

GO:0006281

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0007064

GO:0008092

GO:0008278

GO:0016363

GO:0016787

GO:0016887

GO:0019827

GO:0022414

GO:0030312

GO:0030893

GO:0031012

GO:0036033

GO:0043226

GO:0046982

GO:0048487

GO:0051276

GO:0051301

GO:0051321

GO:0061775

GO:0070840

GO:0090307

GO:0097431

GO:0140014

GO:0140097

GO:0140657

ILMN_1223531

ILMN_2602761

ILMN_2604080

ILMN_2678413

aa209705_s_at

mMC006421

mMC021385

mMC022459

mMR001358

Participates

as a component of

Other forms of this molecule

SMC3 [cytosol]

2xAcK-SMC3 [cytosol]

2xAcK-SMC3 [chromosome, centromeric region]

2xAcK-SMC3 [nucleoplasm]

Structural maintenance of chromosomes protein 3 [nucleoplasm]

Inferred From

2xAcK-SMC3 [chromosome] (Homo sapiens)

Modified Residues

Name

N6-acetyl-L-lysine at 105 (in Homo sapiens)

Coordinate

105

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 106 (in Homo sapiens)

Coordinate

106

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_031816.2

Ensembl

ENSMUST00000025930, ENSMUSP00000025930, ENSMUSG00000024974

PRO

Q9CW03

MGI

1339795

PDB

2WD5, 7DG5

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775)	0.597	5
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.597	4
UniProt:Q61550 Rad21	15	Rad21 [nucleoplasm] (R-MMU-3108183) Double-strand-break repair protein rad21 homolog [nucleoplasm] (R-MMU-912350) phospho-Rad21 [cytosol] (R-MMU-2500310) phospho-Rad21 [chromosome] (R-MMU-2485164) Rad21 [cytosol] (R-MMU-2484795) phospho-Rad21 [cytosol] (R-MMU-2500309) Rad21 [cytosol] (R-MMU-2500308) Rad21 [cytosol] (R-MMU-2484901) Rad21 [chromosome, centromeric region] (R-MMU-2500296) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2467790) Rad21 [chromosome, centromeric region] (R-MMU-2467793) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2485163) Rad21 [chromosome] (R-MMU-1638775) Rad21 [chromosome, centromeric region] (R-MMU-2466012) Rad21 [nucleoplasm] (R-MMU-163042)	0.564	2
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.564	3