Laminin binds galactosyl sulfatide and related sulfated glycolipids

Stable Identifier
R-MMU-2465886
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Laminin binds galactosyl sulfatide and related sulfated glycolipids

Sulfated glycolipids (SGs) such as the sulfatides bind strongly to LG domains 4-5 of laminin (Roberts et al. 1985,1986, Ishizuka 1997, Talts et al. 1999, Harrison et al. 2007). The most common sulfated glycolipid HSO3-3galactosylBeta-1ceramide (galactosyl-3-sulfate ceramide or sulfatide) is highly expressed in developing and adult peripheral nerves (Mirsky et al. 1990), Schwann cells, kidney and other tissues. SGs are thought to mediate or enhance the cell surface anchorage of laminins, possibly by allowing the short arms to bind the cell surface in addition to the LG domains (Li et al. 2005, Yurchenko & Patton 2009).

Literature References
PubMed ID Title Journal Year
3486185 Comparison of the specificities of laminin, thrombospondin, and von Willebrand factor for binding to sulfated glycolipids

Roberts, DD, Rao, CN, Liotta, LA, Gralnick, HR, Ginsburg, V

J. Biol. Chem. 1986
3856264 Laminin binds specifically to sulfated glycolipids

Roberts, DD, Rao, CN, Magnani, JL, Spitalnik, SL, Liotta, LA, Ginsburg, V

Proc. Natl. Acad. Sci. U.S.A. 1985
Participants
Orthologous Events
Authored
Reviewed
Created
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