Reactome | phospho-Ms4a2 [plasma membrane]

phospho-Ms4a2 [plasma membrane]

Stable Identifier

R-MMU-2454226

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-Y219,Y225,Y229-MS4A2, P20490

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated Ca+2 mobilization (Mus musculus)
      - Phosphorylation of TEC kinases by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Phosphorylation of SHC by SYK kinase (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - FCERI mediated NF-kB activation (Mus musculus)
      - Phosphorylation of PKC-theta (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - Phosphorylation of LAT by p-SYK (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - Phosphorylation of beta and gamma subunits by LYN (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI aggregate [plasma membrane] (Mus musculus)
        
        p-FCERI [plasma membrane] (Mus musculus)
        
        phospho-Ms4a2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P20490

Gene Names

Ms4a2

Reference Genes

BioGPS Gene:14126 Ms4a2

ENSEMBL:ENSMUSG00000024680

ENSEMBL:ENSMUSG00000024680.13 Ms4a2

KEGG Gene (Mus musculus):14126 Ms4a2

Monarch:14126 Ms4a2

NCBI Gene:14126 Ms4a2

UCSC:P20490 Ms4a2

Reference Transcript

RefSeq:NM_013516.2 Ms4a2

Other Identifiers

10466216

14126

1421475_at

17362986

4318990

4334605

4475161

4524582

4564427

4819994

4910270

4944587

5564431

96509_at

A_51_P234975

A_55_P2176015

GE119668

GO:0002376

GO:0005768

GO:0005886

GO:0006955

GO:0007165

GO:0007166

GO:0007205

GO:0009897

GO:0016020

GO:0016192

GO:0019767

GO:0019863

GO:0019901

GO:0023052

GO:0031410

GO:0032998

GO:0038095

GO:0042169

GO:0043226

GO:0043306

GO:0045121

GO:0051219

GO:0051279

GO:0055065

GO:0055085

GO:0060089

ILMN_2742703

J05019_s_at

U90218_s_at

mMC017030

Participates

as a component of

p-FCERI [plasma membrane] (Mus musculus)

Other forms of this molecule

Ms4a2 [plasma membrane]

Inferred From

p-Y219,Y225,Y229-MS4A2 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 219 (in Homo sapiens)

Coordinate

219

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 225 (in Homo sapiens)

Coordinate

225

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 229 (in Homo sapiens)

Coordinate

229

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_038544.1

Ensembl

ENSMUST00000164792, ENSMUSP00000127373, ENSMUSG00000024680

PRO

P20490

MGI

95495

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