Laminins:Nidogens binds HSPG2

Stable Identifier
R-MMU-2426528
Type
Reaction [binding]
Species
Mus musculus
Compartment
Synonyms
Laminins:Nidogens binds perlecan
General
SVG |   | PPTX  | SBGN
Laminins:Nidogens binds HSPG2

The IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogen-1, binding to the G2 domain. Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001). Perlecan also binds to nidogen-2 (Battaglia et al. 1992, Reinhardt et al. 1993, Kohfeldt et al. 1998).

Literature References
PubMed ID Title Journal Year
11574465 Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan

Kvansakul, M, Hopf, M, Ries, A, Timpl, R, Hohenester, E

EMBO J. 2001
Participants
Orthologous Events
Authored
Reviewed
Created
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