Laminins:Nidogens binds HSPG2

Stable Identifier
R-MMU-2426528
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region
Synonyms
Laminins:Nidogens binds perlecan
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Laminins:Nidogens binds HSPG2
The IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogen-1, binding to the G2 domain. Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001). Perlecan also binds to nidogen-2 (Battaglia et al. 1992, Reinhardt et al. 1993, Kohfeldt et al. 1998).
Literature References
PubMed ID Title Journal Year
11574465 Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan

Ries, A, Hohenester, E, Hopf, M, Timpl, R, Kvansakul, M

EMBO J. 2001
Participants
Input
Output
Orthologous Events
Laminins:Nidogens binds HSPG2 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-08-03)
Cite Us!