Extracellular CR:atREs are transported to cytosol by Ldlr

Stable Identifier
R-MMU-2425403
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
General
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Extracellular CR:atREs are transported to cytosol by Ldlr
Chylomicron remnants (CRs) are "sieved" when they arrive at the liver by size, the appropriate sized remnants passing through the space of Disse. Once inside, CRs containing all-trans-retinyl esters (atREs) can be directly and rapidly taken up by liver parenchymal cells via the low-density lipoprotein receptor (Ldlr) using apolipoprotein E (Apoe) as a ligand. This process has been demonstrated in mice uptake studies (Yu et al. 2000).
Literature References
PubMed ID Title Journal Year
11060341 Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E

Chen, W, Cooper, AD, Yu, KC, Jiang, Y

J. Lipid Res. 2000
Participants
Input
Output
Catalyst Activity

low-density lipoprotein particle receptor activity of Ldlr [plasma membrane]

Physical Entity
Ldlr [plasma membrane] (Mus musculus)
Activity
low-density lipoprotein particle receptor activity (GO:0005041)
Orthologous Events
LDLR transports extracellular CR:atREs to cytosol (Homo sapiens)
Authored
Jassal, B  (2012-07-25)
Created
Jassal, B  (2012-07-25)
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