Rab4a:GTP Activates Kif3

Stable Identifier
R-MMU-2316350
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytoplasmic vesicle membrane, cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Rab4a:GTP Activates Kif3
Insulin signals via PKC-lambda to cause Rab4 to load GTP and associate with Kif3, which then has higher affinity for microtubules (Imamura et al. 2003). Motor activity of Kif3 along microtubules is believed to transport vesicles containing Glut4 (Slc2a4) across the cytosol to the cortical actin network.
Literature References
PubMed ID Title Journal Year
12832475 Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

Olefsky, JM, Satoh, H, Usui, I, Huang, J, Bever, J, Imamura, T

Mol Cell Biol 2003
Participants
Input
Output
Orthologous Events
RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)
Authored
May, B  (2012-05-27)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-06-08)
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