Rab4a:GTP Activates Kif3

Stable Identifier
R-MMU-2316350
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Rab4a:GTP Activates Kif3

Insulin signals via PKC-lambda to cause Rab4 to load GTP and associate with Kif3, which then has higher affinity for microtubules (Imamura et al. 2003). Motor activity of Kif3 along microtubules is believed to transport vesicles containing Glut4 (Slc2a4) across the cytosol to the cortical actin network.

Literature References
PubMed ID Title Journal Year
12832475 Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

Olefsky, JM, Satoh, H, Usui, I, Huang, J, Bever, J, Imamura, T

Mol Cell Biol 2003
Participants
Orthologous Events
Authored
Reviewed
Created
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